Escaping stochastic extinction of mutant virus: temporal pattern of emergence of drug resistance within a host

DOI10.1016/J.JTBI.2022.111029MaRDI QIDQ2670168zbMATH OpenOpenAlexWikidataFDO

Authors Rena Hayashi, Shingo Iwami, Yoh Iwasa

Publication date 10 March 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111029

zbMATH Keywords

drug resistanceescape mutanttime-dependent branching processesviral dynamics

Mathematics Subject Classification ID

Applications of branching processes (60J85) Medical epidemiology (92C60) Epidemiology (92D30)

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Cites work

• Branching Processes
• Escape times for branching processes with random mutational fitness effects
• Estimating the transmission potential of supercritical processes based on the final size distribution of minor outbreaks
• Evolutionary dynamics of invasion and escape
• scientific article; zbMATH DE number 2038872 (Why is no real title available?)
• Production of resistant HIV mutants during antiretroviral therapy
• Some Problems of Stochastic Processes in Genetics
• Understanding hepatitis C viral dynamics with direct-acting antiviral agents due to the interplay between intracellular replication and cellular infection dynamics
• Virulence of a virus: how it depends on growth rate, effectors, memory cells, and immune escape

Cited in

(11)

• Waves of infection emerging from coupled social and epidemiological dynamics
• Probability of resistance evolution for exponentially growing virus in the host
• On the probability of strain invasion in endemic settings: accounting for individual heterogeneity and control in multi-strain dynamics
• Emergence of resistance in influenza with compensatory mutations
• Drug resistance in acute viral infections: rhinovirus as a case study
• Drug concentration heterogeneity facilitates the evolution of drug resistance
• Learning the language of viral evolution and escape
• Temporal pattern of the emergence of a mutant virus escaping cross-immunity and stochastic extinction within a host
• Viral rebound occurrence immediately after drug discontinuation involving neither drug resistance nor latent reservoir
• Modeling mutation-driven emergence of drug-resistance: a case study of SARS-CoV-2
• Quantifying relative within-host replication fitness in influenza virus competition experiments

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