Dynamics of HIV infection of CD4^ + T cells

DOI10.1016/0025-5564(93)90043-AzbMATH Open0796.92016WikidataQ52400530 ScholiaQ52400530MaRDI QIDQ1802910FDOQ1802910

Authors: Alan S. Perelson, Denise E. Kirschner, Rob J. De Boer 

Publication date: 29 June 1993

Published in: Mathematical Biosciences (Search for Journal in Brave)

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zbMATH Keywords

differential equationsimmune responsenumerical analysisdynamics of HIV infectionT-cell depletionT-cell replenishment

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

Cites Work

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• Mathematical biology of HIV infections: Antigenic variation and diversity threshold
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Cited In (only showing first 100 items - show all)

• Dynamics of two time delays differential equation model to HIV latent infection
• Optimal control in HIV chemotherapy with termination viral load and latent reservoir
• Estimating the approximate analytical solution of HIV viral dynamic model by using homotopy analysis method
• Estimation of the HIV-1 infection rate and the basic reproductive ratio
• A numerical efficient splitting method for the solution of HIV time periodic reaction-diffusion model having spatial heterogeneity
• Twin solutions to semipositone boundary value problems for fractional differential equations with coupled integral boundary conditions
• Existence theory and numerical simulation of HIV-I cure model with new fractional derivative possessing a non-singular kernel
• Insight on treatment of HIV-1 infection on populace of \(\mathcal{CD}4^+T\)-cells based on a fractional differential model
• Effect of delayed immune response on the dynamics of HIV infection under multidrug treatment
• Modelling intracellular delay and therapy interruptions within Ghanaian HIV population
• Stability and dynamic of HIV-1 mathematical model with logistic target cell growth, treatment rate, cure rate and cell-to-cell spread
• Stationary distribution of an HIV model with general nonlinear incidence rate and stochastic perturbations
• MODELING MONOCYTE-DERIVED DENDRITIC CELLS AS A THERAPEUTIC VACCINE AGAINST HIV
• Asymptotical profiles of a viral infection model with multi-target cells and spatial diffusion
• Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains
• Structure preserving numerical analysis of HIV and CD4+T-cells reaction diffusion model in two space dimensions
• Stability analysis and memetic computation using differential evolution for in-host HIV model
• A delayed HIV infection model with the homeostatic proliferation of CD\(4^+\) T cells
• Singly diagonally implicit block backward differentiation formulas for HIV infection of CD\(4^+\)T cells
• Global properties of a general latent pathogen dynamics model with delayed pathogenic and cellular infections
• Virus dynamic behavior of a stochastic HIV/AIDS infection model including two kinds of target cell infections and CTL immune responses
• Stationary distribution and extinction of a stochastic HIV-1 model with Beddington-DeAngelis infection rate
• A numerical comparison for a discrete HIV infection of CD4\(^{+}\) T-cell model derived from nonstandard numerical scheme
• Effects of eclipse phase and delay on the dynamics of HIV infection
• Analysis of an HTLV/HIV dual infection model with diffusion
• Dynamics of a new HIV model with the activation status of infected cells
• An age-structured within-host HIV-1 infection model with virus-to-cell and cell-to-cell transmissions
• Modeling within-host viral dynamics: the role of CTL immune responses in the evolution of drug resistance
• Bifurcation analysis of an age structured HIV infection model with both virus-to-cell and cell-to-cell transmissions
• Effect of innate and adaptive immune mechanisms on treatment regimens in an AIDS-related Kaposi's Sarcoma model
• Calculating all multiple parameter solutions of ODE models to avoid biological misinterpretations
• Mathematical analysis of an age-structured HIV-1 infection model with CTL immune response
• Age-structured viral dynamics in a host with multiple compartments
• Mathematical analysis of an HBV model with antibody and spatial heterogeneity
• Optimal control strategies for tuberculosis dynamics with exogenous reinfections in case of treatment at home and treatment in hospital
• A mathematical model for the role of macrophages in the persistence and elimination of oncolytic viruses
• Spatiotemporal dynamics for a diffusive HIV-1 infection model with distributed delays and CTL immune response
• Dynamics of an HIV infection model with two infection routes and evolutionary competition between two viral strains
• Time periodic reaction-diffusion equations for modeling 2-LTR dynamics in HIV-infected patients
• Viral infection dynamics in a spatial heterogeneous environment with cell-free and cell-to-cell transmissions
• Numerical solution of fractional-order HIV model using homotopy method
• Shifted Boubaker Lagrangian approach for solving biological systems
• Analysis and computation of multi-pathways and multi-delays HIV-1 infection model
• Optimal treatment strategies for HIV with antibody response
• The effect of delay in viral production in within-host models during early infection
• THE COUPLED WITHIN-AND BETWEEN-HOST DYNAMICS IN THE EVOLUTION OF HIV/AIDS IN CHINA
• The impact of nonlinear stochastic perturbation on dynamical behavior of an HIV infection system
• Dynamical behaviour of HIV infection with the influence of variable source term through Galerkin method
• The Chebyshev wavelet method (CWM) for the numerical solution of fractional HIV infection of CD\(4^+\) T cells model
• Towards a new combination therapy with vectored immunoprophylaxis for HIV: modeling ``Shock and kill strategy
• A second order accurate approximation for fractional derivatives with singular and non-singular kernel applied to a HIV model
• Mathematical analysis of the role of HIV/HBV latency in hepatocytes
• Analysis of a stochastic HIV model with cell-to-cell transmission and Ornstein–Uhlenbeck process
• Modeling HIV dynamics under combination therapy with inducers and antibodies
• Reaction-diffusion equations in immunology
• Mathematical modeling of impact of eCD4-ig molecule in control and management of HIV within a host
• Study of HIV mathematical model under nonsingular kernel type derivative of fractional order
• MATHEMATICAL ANALYSIS AND SIMULATION OF A GIVING UP SMOKING MODEL WITHIN THE SCOPE OF NON-SINGULAR DERIVATIVE
• Resistance to protease inhibitors in a model of HIV-1 infection with impulsive drug effects
• Mutation and control of the human immunodeficiency virus
• Nonlinear dynamics and chaos in a fractional-order HIV model
• Stability analysis of within-host parasite models with delays
• Modelling two different therapy strategies for drug T-20 on HIV-1 patients
• Some state space models of HIV pathogenesis under treatment by anti-viral drugs in HIV-infected individuals
• Modeling the role of acquired immune response and antiretroviral therapy in the dynamics of HIV infection
• Mathematical modeling of HIV-1 infection and drug therapy
• Solving a system of fractional partial differential equations arising in the model of HIV infection of \(\mathrm{CD4}^{+}\) cells and attractor one-dimensional Keller-Segel equations
• Stability analysis for delayed viral infection model with multitarget cells and general incidence rate
• Epidemic dynamics and host immune response: a nested approach
• The T cells in an ageing virtual mouse
• Global asymptotic stability for the disease free equilibrium for epidemiological models
• A dynamical model of human immune response to influenza A virus infection
• The global dynamics of a model about HIV-1 infection in vivo
• Multiscale modelling of cancer response to oncolytic viral therapy
• A time delay model about AIDS-related cancer: equilibria, cycles and chaotic behavior
• Viral diffusion and cell-to-cell transmission: mathematical analysis and simulation study
• Mathematical Models of the Complete Course of HIV Infection and AIDS
• A mathematical model for chronic myelogenous leukemia (CML) and T cell interaction
• A mathematical model of HIV infection: Simulating T4, T8 macrophages, antibody, and virus via specific anti-HIV response in the presence of adaptation and tropism
• A Comparison Study of Models and Fitting Procedures for Biphasic Viral Dynamics in HIV‐1 Infected Patients Treated with Antiviral Therapies
• Impulsive control of single-input nonlinear systems with application to HIV dynamics
• A mathematical model for HIV treatment with time-varying antiretroviral therapy
• An HIV model with age-structured latently infected cells
• Threshold dynamics for an HIV model in periodic environments
• An accurate two-phase approximate solution to an acute viral infection model
• Backward bifurcation in a mathematical model for HIV infection \textit{in vivo} with anti-retroviral treatment
• Global dynamics of a PDE in-host viral model
• First passage time to detection in stochastic population dynamical models for HIV-1
• Hopf bifurcation in a CTL-inclusive HIV-1 infection model with two time delays
• Viral dynamics model with CTL immune response incorporating antiretroviral therapy
• Threshold virus dynamics with impulsive antiretroviral drug effects
• A fractional-order model of HIV infection with drug therapy effect
• An exponential matrix method for solving systems of linear differential equations
• Stochastic model for Langerhans cells and HIV dynamics in vivo
• Impact of gene-modified T cells on HIV infection dynamics
• A latency fractional order model for HIV dynamics
• HIV dynamics: analysis and robust multirate MPC-based treatment schedules
• Modelling HIV dynamics with cell‐to‐cell transmission and CTL response
• Global dynamics for viral infection model with Beddington-Deangelis functional response and an eclipse stage of infected cells
• Stability and Hopf bifurcation in a delayed model for HIV infection of CD\(4^+\) T cells

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