Estimation of the HIV-1 backward mutation rate from transmitted drug-resistant strains

DOI10.1016/J.TPB.2016.08.001MaRDI QIDQ2011533zbMATH OpenOpenAlexWikidataFDO

Authors J. Y. T. Mugisha, John M. Kitayimbwa, Roberto A. Saenz

Publication date 4 August 2017

Published in Theoretical Population Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.tpb.2016.08.001

zbMATH Keywords

HIV-1within-host modelvirus mutationsKaplan-Meier estimatesbackward mutation rate

Mathematics Subject Classification ID

Epidemiology (92D30) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Recommendations

• The role of backward mutations on the within-host dynamics of HIV-1
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Cites work

• Dynamics of HIV infection of CD4\(^ +\) T cells
• Emergence of HIV-1 drug resistance during antiretroviral treatment
• Monte Carlo estimates of natural variation in HIV infection
• Production of resistant HIV mutants during antiretroviral therapy
• The role of backward mutations on the within-host dynamics of HIV-1

Cited in

(3)

• Dynamic analysis of conversion from a drug-sensitivity strain to a drug-resistant strain
• Characterization of differential susceptibility and differential infectivity epidemic models
• Combining Cross‐Sectional and Prospective Data Methods to Improve Transition Parameter Estimation for Characterizing the Accumulation of HIV‐1 Drug Resistance Mutations

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