An investigation of tuberculosis progression revealing the role of macrophages apoptosis via sensitivity and bifurcation analysis
DOI10.1007/S00285-021-01655-6zbMATH Open1479.34087OpenAlexW3193620403WikidataQ113905473 ScholiaQ113905473MaRDI QIDQ2232136FDOQ2232136
Authors: Wenjing Zhang, Leif Ellingson, Federico Frascoli, Jane M. Heffernan 
Publication date: 4 October 2021
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/s00285-021-01655-6
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disease progressionin-host tuberculosis infection modelsensitivity analysis and bifurcation analysistuberculosis treatments
Medical applications (general) (92C50) Medical epidemiology (92C60) Qualitative investigation and simulation of ordinary differential equation models (34C60) Sensitivity (robustness) (93B35) Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Transformation and reduction of ordinary differential equations and systems, normal forms (34C20) Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20)
Cites Work
- Rank Transformations as a Bridge Between Parametric and Nonparametric Statistics
- Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
- A Comparison of Three Methods for Selecting Values of Input Variables in the Analysis of Output from a Computer Code
- Dynamics of co-infection with M. tuberculosis and HIV-1
- MATCONT
- Criterion of Hopf bifurcations without using eigenvalues
- A methodology for performing global uncertainty and sensitivity analysis in systems biology
- Identifying control mechanisms of granuloma formation during \textit{M. tuberculosis} infection using an agent-based model
- Modelling the human immune response mechanisms to Mycobacterium tuberculosis infection in the lungs
- A simple in-host model for Mycobacterium tuberculosis that captures all infection outcomes
- The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node
- CLOSED-FORM CONDITIONS OF BIFURCATION POINTS FOR GENERAL DIFFERENTIAL EQUATIONS
- Analysis of solutions and disease progressions for a within-host Tuberculosis model
- The effects of HIV-1 infection on latent tuberculosis
- Modeling the spread and control of dengue with limited public health resources
- Analysis on recurrence behavior in oscillating networks of biologically relevant organic reactions
- A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes
Cited In (5)
- Bifurcations of a cancer immunotherapy model explaining the transient delayed response and various other responses
- Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy
- Modelling the human immune response mechanisms to Mycobacterium tuberculosis infection in the lungs
- Exploring Hopf-bifurcations and endemic bubbles in a tuberculosis model with behavioral changes and treatment saturation
- Macrophage response to \textit{Mycobacterium tuberculosis} infection
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