Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle

DOI10.1016/J.JTBI.2020.110381zbMath1455.92075OpenAlexW3048311904WikidataQ98282874 ScholiaQ98282874MaRDI QIDQ827728

Ruth Bowness, Stephen H. Gillespie, Simon Dobson, Michael J. Pitcher, Raluca Eftimie

Publication date: 13 January 2021

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2020.110381

zbMATH Keywords

localisationtuberculosiscomputational biologymetapopulationbacteriawithin-host modellung

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Related Items (1)

A virtual host model of \textit{Mycobacterium tuberculosis} infection identifies early immune events as predictive of infection outcomes

Cites Work

• A hybrid multi-compartment model of granuloma formation and T cell priming in tuberculosis
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Identifying control mechanisms of granuloma formation during \textit{M. tuberculosis} infection using an agent-based model
• The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node
• Modelling the human immune response mechanisms to Mycobacterium tuberculosis infection in the lungs
• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment

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