A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment

DOI10.1016/J.JTBI.2014.11.021MaRDI QIDQ2415779zbMATH OpenOpenAlexWikidataFDO

Authors E. Pienaar, Nicholas A. Cilfone, Philana Ling Lin, Véronique Dartois, Joshua T. Mattila, J. Butler, Joanne Flynn, Denise E. Kirschner, Jennifer J. Linderman

Publication date 23 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.11.021

zbMATH Keywords

pharmacodynamicspharmacokineticsagent based modelgranulomaantibiotic gradients

Mathematics Subject Classification ID

Medical epidemiology (92C60) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• scientific article; zbMATH DE number 2232255 (Why is no real title available?)
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• A model of isoniazid treatment of tuberculosis
• Fast Fourier transform method for partial differential equations, case study: The 2-D diffusion equation
• Identifying control mechanisms of granuloma formation during \textit{M. tuberculosis} infection using an agent-based model
• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• On the optimality of the simple Bayesian classifier under zero-one loss

Cited in

(6)

• A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment
• Modeling basic aspects of bacterial resistance of Mycobacterium tuberculosis to antibiotics
• Modeling nanoparticle delivery of TB drugs to granulomas
• Mathematical modeling and systems pharmacology of tuberculosis: isoniazid as a case study
• Mathematical modeling of pulmonary tuberculosis therapy: insights from a prototype model with rifampin
• Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle

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