A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment
DOI10.1016/J.MBS.2023.108983zbMATH Open1519.92096OpenAlexW4324365189MaRDI QIDQ6133977FDOQ6133977
Authors: Christopher Denaro, Nathaniel J. Merrill, Sean T. McQuade, Logan Reed, Karim Azer, B. Piccoli 
Publication date: 25 July 2023
Published in: Mathematical Biosciences (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.mbs.2023.108983
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Medical applications (general) (92C50) Systems biology, networks (92C42) Computational methods for problems pertaining to biology (92-08)
Cites Work
- Qualitative Theory of Compartmental Systems
- Introduction to graph and hypergraph theory
- Hypergraph theory. An introduction
- Asymptotic behavior of nonlinear compartmental systems: Nonoscillation and stability
- Stability of metabolic networks via linear-in-flux-expressions
- Metabolic graphs, the LIFE method, and modeling drug action on \textit{Mycobacterium tuberculosis}
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- A novel ensemble based recommendation approach using network based analysis for identification of effective drugs for tuberculosis
- Metabolic graphs, the LIFE method, and modeling drug action on \textit{Mycobacterium tuberculosis}
- Applying quantitative systems pharmacology (QSP) modeling to understand the treatment of \textit{Pneumocystis}
- Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes
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