A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment

DOI10.1016/J.MBS.2023.108983MaRDI QIDQ6133977zbMATHOpenAlexFDO

Authors Christopher Denaro, Nathaniel J. Merrill, Sean T. McQuade, Logan Reed, Karim Azer, B. Piccoli

Publication date 25 July 2023

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.mbs.2023.108983

zbMATH Keywords

metabolic networksQSPcomputational pipelinelinear in flux expressions (LIFE)

Mathematics Subject Classification ID

Medical applications (general) (92C50) Systems biology, networks (92C42) Computational methods for problems pertaining to biology (92-08)

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Cites work

• Asymptotic behavior of nonlinear compartmental systems: Nonoscillation and stability
• Hypergraph theory. An introduction
• Introduction to graph and hypergraph theory
• Metabolic graphs, the LIFE method, and modeling drug action on \textit{Mycobacterium tuberculosis}
• Qualitative Theory of Compartmental Systems
• Stability of metabolic networks via linear-in-flux-expressions

Cited in

(4)

• Algorithms and methodological challenges in the development and application of quantitative systems pharmacology models: a case study in type 2 diabetes
• A novel ensemble based recommendation approach using network based analysis for identification of effective drugs for tuberculosis
• Applying quantitative systems pharmacology (QSP) modeling to understand the treatment of \textit{Pneumocystis}
• Metabolic graphs, the LIFE method, and modeling drug action on \textit{Mycobacterium tuberculosis}

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