A pipeline for testing drug mechanism of action and combination therapies: from microarray data to simulations via linear-in-flux-expressions. Testing four-drug combinations for tuberculosis treatment

DOI10.1016/J.MBS.2023.108983zbMATH Open1519.92096OpenAlexW4324365189MaRDI QIDQ6133977FDOQ6133977

Nathaniel J. Merrill, Christopher Denaro, Logan Reed, B. Piccoli, Karim Azer, Sean T. McQuade

Publication date: 25 July 2023

Published in: Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.mbs.2023.108983

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zbMATH Keywords

metabolic networksQSPcomputational pipelinelinear in flux expressions (LIFE)

Mathematics Subject Classification ID

Medical applications (general) (92C50) Systems biology, networks (92C42) Computational methods for problems pertaining to biology (92-08)

Cites Work

• Qualitative Theory of Compartmental Systems
• Title not available (Why is that?)
• Hypergraph theory. An introduction
• Asymptotic behavior of nonlinear compartmental systems: Nonoscillation and stability
• Stability of metabolic networks via linear-in-flux-expressions
• Title not available (Why is that?)

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