A virtual host model of \textit{Mycobacterium tuberculosis} infection identifies early immune events as predictive of infection outcomes

DOI10.1016/J.JTBI.2022.111042MaRDI QIDQ2116000zbMATH OpenOpenAlexWikidataFDO

Authors Louis R. Joslyn, Jennifer J. Linderman, Denise E. Kirschner

Publication date 15 March 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111042

zbMATH Keywords

digital twinsmechanistic modelingmulti-scale modelingsystems biologyT cellstuberculosis

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32) Systems biology, networks (92C42)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• scientific article; zbMATH DE number 720689 (Why is no real title available?)
• scientific article; zbMATH DE number 194949 (Why is no real title available?)
• Identifying control mechanisms of granuloma formation during \textit{M. tuberculosis} infection using an agent-based model
• Modelling the effects of environmental heterogeneity within the lung on the tuberculosis life-cycle
• The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node

Cited in

(9)

• Deciphering the virulence of \textit{Mycobacterium avium} subsp. \textit{paratuberculosis} isolates in animal macrophages using mathematical models
• Modeling innate immune response to early Mycobacterium infection
• The role of biofilms, bacterial phenotypes, and innate immune response in \textit{Mycobacterium avium} colonization to infection
• The human immune response to \textit{Mycobacterium tuberculosis} in lung and lymph node
• A population model capturing dynamics of tuberculosis granulomas predicts host infection outcomes
• A computational tool integrating host immunity with antibiotic dynamics to study tuberculosis treatment
• The role of dendritic cells and other immune mechanisms during human infection with \textit{Mycobacterium tuberculosis}
• COVID-19-associated pulmonary aspergillosis in immunocompetent patients: a virtual patient cohort study
• Rankings of tuberculosis antibiotic treatment regimens are sensitive to spatial scale, detection limit, and initial host bacterial burden

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