Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes

DOI10.1016/j.jtbi.2015.07.032zbMath1343.92279OpenAlexW1155846412WikidataQ36054301 ScholiaQ36054301MaRDI QIDQ739419

Majid Jaberi-Douraki, Massimo Pietropaolo, Anmar Khadra

Publication date: 18 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: http://europepmc.org/articles/pmc4567915

zbMATH Keywords

mathematical modelavidity-dependent dominancehoneymoon periodimmunomodulationinter- and intra-clonal competition

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

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Cites Work

• Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation
• Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity
• Modeling regulation mechanisms in the immune system
• Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?