Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes

DOI10.1016/J.JTBI.2015.07.032MaRDI QIDQ739419zbMATH OpenOpenAlexWikidataFDO

Authors Majid Jaberi-Douraki, Massimo Pietropaolo, Anmar Khadra

Publication date 18 August 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc4567915

zbMATH Keywords

avidity-dependent dominancehoneymoon periodimmunomodulationinter- and intra-clonal competitionmathematical model

Mathematics Subject Classification ID

Medical applications (general) (92C50) Medical epidemiology (92C60)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity
• Modeling regulation mechanisms in the immune system
• Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?
• The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation
• Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes

Cited in

(10)

• The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation
• The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation
• Modeling dynamic changes in type 1 diabetes progression: quantifying \(\beta\)-cell variation after the appearance of islet-specific autoimmune responses
• A mathematical model of T1D acceleration and delay by viral infection
• Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
• Automatic Recognition of Muscle-Invasive T-Lymphocytes Expressing Dipeptidyl-Peptidase IV (CD26) and Analysis of the Associated Cell Surface Phenotypes
• Modeling Cyclic Waves of Circulating T Cells in Autoimmune Diabetes
• Modelling the impact of NETosis during the initial stage of systemic lupus erythematosus
• Quantifying macrophage defects in type 1 diabetes
• Investigation of the age-at-onset heterogeneity in type 1 diabetes through mathematical mod\-el\-ing

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