The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation

DOI10.1016/J.JTBI.2008.09.019MaRDI QIDQ1798658zbMATH OpenOpenAlexWikidataFDO

Authors Anmar Khadra, Pere Santamaria, Leah Edelstein-Keshet

Publication date 23 October 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2008.09.019

zbMATH Keywords

\(\beta\) cellantigen-presenting cell (APC)diabetesmodelingT cell avidity

Mathematics Subject Classification ID

Physiology (general) (92C30) Medical applications (general) (92C50)

Recommendations

• Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes
• Modeling dynamic changes in type 1 diabetes progression: quantifying \(\beta\)-cell variation after the appearance of islet-specific autoimmune responses
• Modeling Cyclic Waves of Circulating T Cells in Autoimmune Diabetes
• Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
• The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation

Cites work

• G-CSF control of neutrophils dynamics in the blood
• Modeling Cyclic Waves of Circulating T Cells in Autoimmune Diabetes
• Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?
• Quantifying macrophage defects in type 1 diabetes

Cited in

(10)

• Modeling immune complex-mediated autoimmune inflammation
• Dependence of CD8 T cell response upon antigen load during primary infection.
• The dual role of autoimmune regulator in maintaining normal expression level of tissue-restricted autoantigen in the thymus: a modeling investigation
• Modeling dynamic changes in type 1 diabetes progression: quantifying \(\beta\)-cell variation after the appearance of islet-specific autoimmune responses
• A mathematical model of T1D acceleration and delay by viral infection
• Unraveling the contribution of pancreatic beta-cell suicide in autoimmune type 1 diabetes
• Modelling the onset of Type 1 diabetes: can impaired macrophage phagocytosis make the difference between health and disease?
• Theoretical quantification of the polyvalent binding of nanoparticles coated with peptide-major histocompatibility complex to T cell receptor-nanoclusters
• Continuum model of T-cell avidity: understanding autoreactive and regulatory T-cell responses in type 1 diabetes
• Quantifying macrophage defects in type 1 diabetes

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