Theoretical quantification of the polyvalent binding of nanoparticles coated with peptide-major histocompatibility complex to T cell receptor-nanoclusters

DOI10.1016/J.MBS.2023.108995zbMath1519.92069MaRDI QIDQ6157790

Anmar Khadra, Louis Richez, Manuela Pineros-Rodriguez

Publication date: 22 June 2023

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

Gibbs free energycooperativitymultiscale modeldissociation constantdensity of bound and triggered TCRsinsertion probabilitypMHC-coated nanoparticlespolyvalent bidingT cell receptorsTCR nanoclusters

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37)

Cites Work

• Receptor clustering on a cell surface. I. Theory of receptor cross- linking by ligands bearing two chemically identical functional groups
• Receptor clustering on a cell surface. III. Theory of receptor cross- linking by multivalent ligands: Description by ligand states
• Stochastic effects and bistability in T cell receptor signaling
• The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation

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