Theoretical quantification of the polyvalent binding of nanoparticles coated with peptide-major histocompatibility complex to T cell receptor-nanoclusters

DOI10.1016/J.MBS.2023.108995MaRDI QIDQ6157790zbMATH OpenFDO

Authors Manuela Pineros-Rodriguez, Louis Richez, Anmar Khadra

Publication date 22 June 2023

Published in Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

cooperativitymultiscale modelGibbs free energydissociation constantdensity of bound and triggered TCRsinsertion probabilitypMHC-coated nanoparticlespolyvalent bidingT cell receptorsTCR nanoclusters

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37)

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Cites work

• Receptor clustering on a cell surface. I. Theory of receptor cross- linking by ligands bearing two chemically identical functional groups
• Receptor clustering on a cell surface. III. Theory of receptor cross- linking by multivalent ligands: Description by ligand states
• Stochastic effects and bistability in T cell receptor signaling
• The role of low avidity T cells in the protection against type 1 diabetes: a modeling investigation

Cited in

(1)

• A general model of multivalent binding with ligands of heterotypic subunits and multiple surface receptors

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