Reduced model for female endocrine dynamics: validation and functional variations
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Publication:6157780
DOI10.1016/J.MBS.2023.108979zbMATH Open1519.92038arXiv2006.05034OpenAlexW4320487296MaRDI QIDQ6157780FDOQ6157780
Authors: Erica J. Graham, Noémie Elhadad, D. J. Albers 
Publication date: 22 June 2023
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: A normally functioning menstrual cycle requires significant crosstalk between hormones originating in ovarian and brain tissues. Reproductive hormone dysregulation may cause abnormal function and sometimes infertility. The inherent complexity in this endocrine system is a challenge to identifying mechanisms of cycle disruption, particularly given the large number of unknown parameters in existing mathematical models. We develop a new endocrine model to limit model complexity and use simulated distributions of unknown parameters for model analysis. By employing a comprehensive model evaluation, we identify a collection of mechanisms that differentiate normal and abnormal phenotypes. We also discover an intermediate phenotype--displaying relatively normal hormone levels and cycle dynamics--that is grouped statistically with the irregular phenotype. Results provide insight into how clinical symptoms associated with ovulatory disruption may not be detected through hormone measurements alone.
Full work available at URL: https://arxiv.org/abs/2006.05034
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Cited In (9)
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- Modeling the endocrine control of vitellogenin production in female rainbow trout
- Modeling endocrine control of the pituitary-ovarian axis: androgenic influence and chaotic dynamics
- A lifelong model for the female reproductive cycle with an antimüllerian hormone treatment to delay menopause
- Linear dynamics of mRNA expression and hormone concentration levels in primary cultures of bovine granulosa cells
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