Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization

DOI10.1016/J.JTBI.2020.110511MaRDI QIDQ2225984zbMATH OpenOpenAlexWikidataFDO

Authors A. Frank, Kamila Larripa, Hwayeon Ryu, Ryan G. Snodgrass, Susanna Röblitz

Publication date 11 February 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2020.110511

zbMATH Keywords

cellular signalingdynamical systemsphenotypessteady states

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20) Cell biology (92C37)

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Cites work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making
• Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates

Cited in

(9)

• Mathematical modeling of ventilator-induced lung inflammation
• The study of the influence of micro-environmental signals on macrophage differentiation using a quantitative Petri net based model
• Backward bifurcation in neutrophil-pathogen interaction
• Mitochondrial outer membrane permeabilization and inner membrane permeabilization in regulating apoptosis and inflammation
• Macrophage phenotype transitions in a stochastic gene-regulatory network model
• Spectral clustering of Markov chain transition matrices with complex eigenvalues
• Modelling the continuum of macrophage phenotypes and their role in inflammation
• Modeling bistable dynamics arising from macrophage-tumor interactions in the tumor microenvironment
• Modelling the role of macrophage polarization during pulmonary infection of Mycobacterium tuberculosis with cellular immunity

Describes a project that uses

Uses Software

• XPPAUT
• SALib

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