Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization

DOI10.1016/j.jtbi.2020.110511zbMath1457.92050OpenAlexW3091934524WikidataQ100523497 ScholiaQ100523497MaRDI QIDQ2225984

Kamila Larripa, Susanna Röblitz, Hwayeon Ryu, A. Frank, Ryan G. Snodgrass

Publication date: 11 February 2021

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2020.110511

zbMATH Keywords

dynamical systemssteady statesphenotypescellular signaling

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Stability of solutions to ordinary differential equations (34D20) Cell biology (92C37)

Related Items (3)

Mitochondrial outer membrane permeabilization and inner membrane permeabilization in regulating apoptosis and inflammation ⋮ Macrophage phenotype transitions in a stochastic gene-regulatory network model ⋮ Mathematical modeling of ventilator-induced lung inflammation

Uses Software

• XPPAUT
• SALib

Cites Work

• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Combining cytokine signalling with T-bet and GATA-3 regulation in Th1 and Th2 differentiation: a model for cellular decision-making
• Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates

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