Mathematical modeling and bifurcation analysis of pro- and anti-tumor macrophages

DOI10.1016/j.apm.2020.06.042zbMath1481.92070OpenAlexW3040791765MaRDI QIDQ821962

Yueping Dong, Yasuhiro Takeuchi, Ya Qin Shu, Ji-Cai Huang

Publication date: 21 September 2021

Published in: Applied Mathematical Modelling (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.apm.2020.06.042

zbMATH Keywords

mathematical modelbifurcation analysisM1 and M2 macrophagespro- and anti-tumor

Mathematics Subject Classification ID

Bifurcation theory for ordinary differential equations (34C23) Medical applications (general) (92C50) Cell biology (92C37) Qualitative investigation and simulation of ordinary differential equation models (34C60)

Related Items (10)

Bifurcation analysis of a new aquatic ecological model with aggregation effect ⋮ A detailed study on a tumor model with delayed growth of pro-tumor macrophages ⋮ Bifurcation Analysis in a Tumor-Immune System Interaction Model with Dendritic Cell Therapy and Immune Response Delay ⋮ Modeling the role of immune cell conversion in the tumor-immune microenvironment ⋮ Fractional model of brain tumor with chemo-radiotherapy treatment ⋮ Mathematical modelling of the inhibitory role of regulatory T cells in tumor immune response ⋮ Mathematical investigation of the role of re-polarisation of M2 in cancer therapy ⋮ Container throughput analysis and seaport operations management using nonlinear control synthesis ⋮ Modelling and analysis of delayed tumour-immune system with hunting T-cells ⋮ Hopf bifurcation and chaos of tumor-lymphatic model with two time delays

Uses Software

• MATCONT

Cites Work

• Unnamed Item
• Dynamics in a tumor immune system with time delays
• The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes
• A structural methodology for modeling immune-tumor interactions including pro- and anti-tumor factors for clinical applications
• An applicable Hopf bifurcation formula and instability of small periodic solutions of the Field-Noyes model
• The Hopf bifurcation and its applications. With contributions by P. Chernoff, G. Childs, S. Chow, J. R. Dorroh, J. Guckenheimer, L. Howard, N. Kopell, O. Lanford, J. Mallet-Paret, G. Oster, O. Ruiz, S. Schecter, D. Schmidt, and S. Smale
• Modeling immunotherapy of the tumor -- immune interaction
• Macrophage-tumour interactions: In vivo dynamics
• Two limit cycles in three-dimensional Lotka-Volterra systems
• The combined effects of optimal control in cancer remission
• Mathematical modeling of tumor-immune cell interactions
• Stable periodic oscillations in a two-stage cancer model of tumor and immune system interactions
• Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites
• Modelling and investigation of the \(\mathrm{CD}4^+\) T cells -- macrophages paradox in melanoma immunotherapies
• Modeling the dichotomy of the immune response to cancer: cytotoxic effects and tumor-promoting inflammation
• Macrophage-based anti-cancer therapy: Modelling different modes of tumour targeting
• Interactions between the immune system and cancer: A brief review of non-spatial mathematical models
• Mathematical modeling on helper T cells in a tumor immune system
• The influence of time delay in a chaotic cancer model

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