Mathematical modeling of tumor and cancer stem cells treated with CAR-T therapy and inhibition of TGF-

DOI10.1007/S11538-022-01015-5MaRDI QIDQ2127659zbMATH OpenOpenAlexWikidataFDO

Authors Ellen R. Swanson, Emek Kose, Elizabeth A. Zollinger, Samantha L. Elliott

Publication date 21 April 2022

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-022-01015-5

zbMATH Keywords

cancer stem cellCAR-T immunotherapymathematical oncologytransforming growth protein

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Medical applications (general) (92C50)

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Cites work

• A mathematical model for pancreatic cancer growth and treatments
• A mathematical model of the enhancement of tumor vaccine efficacy by immunotherapy
• A mathematical model of tumor-immune evasion and siRNA treatment
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• A multicompartment mathematical model of cancer stem cell-driven tumor growth dynamics
• Control of cell fraction and population recovery during tissue regeneration in stem cell lineages
• Effect of cellular de-differentiation on the dynamics and evolution of tissue and tumor cells in mathematical models with feedback regulation
• Mathematical modelling of cancer stem cell-targeted immunotherapy
• Mathematical modelling of cancer stem cells population behavior
• Modeling the stem cell hypothesis: investigating the effects of cancer stem cells and TGF \(- \beta\) on tumor growth
• Multispecies model of cell lineages and feedback control in solid tumors
• On the proportion of cancer stem cells in a tumour
• The tumor growth paradox and immune system-mediated selection for cancer stem cells
• Tumours with cancer stem cells: a PDE model

Cited in

(8)

• A mathematical model of treatment of cancer stem cells with immunotherapy
• Modeling the stem cell hypothesis: investigating the effects of cancer stem cells and TGF \(- \beta\) on tumor growth
• Mathematical modelling of cancer stem cell-targeted immunotherapy
• Modeling the treatment of glioblastoma multiforme and cancer stem cells with ordinary differential equations
• On the analysis of a mathematical model of CAR-T cell therapy for glioblastoma: insights from a mathematical model
• Effects of a differentiating therapy on cancer-stem-cell-driven tumors
• Integration of immune cell-target cell conjugate dynamics changes the time scale of immune control of cancer
• Mechanisms of resistance to CAR-T cell immunotherapy: insights from a mathematical model

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• FME

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