Mathematical investigation of innate immune responses to lung cancer: the role of macrophages with mixed phenotypes

DOI10.1016/J.JTBI.2021.110739MaRDI QIDQ2031833zbMATH OpenOpenAlexWikidataFDO

Authors R. Eftimie, Charlotte Barelle

Publication date 14 June 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2021.110739

zbMATH Keywords

M1 and M2 macrophagesmacrophages with mixed phenotypesmathematical modellingnon-small cell lung cancer

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32)

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Cites work

• A mathematical model for pancreatic cancer growth and treatments
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Investigation into the role of macrophages heterogeneity on solid tumour aggregations
• Modelling and investigation of the \(\mathrm{CD}4^+\) T cells -- macrophages paradox in melanoma immunotherapies
• Oncolytic viral therapies and the delicate balance between virus-macrophage-tumour interactions: a mathematical approach
• Quantifying T lymphocyte turnover
• Sensitivity and Uncertainty Analysis of Complex Models of Disease Transmission: An HIV Model, as an Example
• The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes

Cited in

(18)

• Role of senescent tumor cells in building a cytokine shield in the tumor microenvironment: mathematical modeling
• Investigation into the role of macrophages heterogeneity on solid tumour aggregations
• Mathematical investigation into the role of macrophage heterogeneity on the temporal and spatio-temporal dynamics of non-small cell lung cancers
• Mathematical investigation of the role of re-polarisation of M2 in cancer therapy
• The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes
• Macrophage phenotype transitions in a stochastic gene-regulatory network model
• Mathematical modeling and quantitative analysis of phenotypic plasticity during tumor evolution based on single-cell data
• Modelling the continuum of macrophage phenotypes and their role in inflammation
• Local and systemic factors in the resolution of inflammation
• Modeling bistable dynamics arising from macrophage-tumor interactions in the tumor microenvironment
• Dynamic analysis of stochastic modeling of tumor-macrophage interactions incorporating multiplicative and additive noises
• Spatio-temporal dynamics of M₁ and M₂ macrophages in a multiphase model of tumor growth
• On discretely structured growth models and their moments
• Mathematical modeling and Hopf bifurcation analysis of tumor macrophage interaction with polarization delay
• A mathematical model to the melanoma dynamics involving car T-cells
• The influence of acute and chronic inflammations on tumor growth
• Macrophage polarization determines inflammation amplification and resolution
• Mathematical model of tumor-macrophage interactions: elucidating the tumor-driven macrophage phenotype reprogramming

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