Mathematical investigation into the role of macrophage heterogeneity on the temporal and spatio-temporal dynamics of non-small cell lung cancers

DOI10.1016/J.JTBI.2022.111207MaRDI QIDQ2676033zbMATH OpenOpenAlexWikidataFDO

Authors Liza Bartha, R. Eftimie

Publication date 27 September 2022

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2022.111207

zbMATH Keywords

cell movementM1 and M2 macrophages with extreme phenotypesmacrophage-targeting cancer treatmentsmacrophages with mixed M1/M2 phenotypesmathematical model of tumour-immune interactionsspatial distribution of different macrophage phenotypes

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17) Pathology, pathophysiology (92C32)

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Cites work

• A mathematical model for pancreatic cancer growth and treatments
• A mathematical model of vascular tumour growth and invasion
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Continuous and discrete mathematical models of tumor-induced angiogenesis
• scientific article; zbMATH DE number 1180836 (Why is no real title available?)
• Investigation into the role of macrophages heterogeneity on solid tumour aggregations
• Macrophage-based anti-cancer therapy: Modelling different modes of tumour targeting
• Mathematical investigation of innate immune responses to lung cancer: the role of macrophages with mixed phenotypes
• Mathematical model of chronic pancreatitis
• Mathematical model of macrophage-facilitated breast cancer cells invasion
• MATHEMATICAL MODELLING OF MACROPHAGE DYNAMICS IN TUMOURS
• Mathematical modelling of the use of macrophages as vehicles for drug delivery to hypoxic tumour sites
• Modelling and investigation of the \(\mathrm{CD}4^+\) T cells -- macrophages paradox in melanoma immunotherapies
• The MATLAB ODE Suite
• The re-polarisation of M2 and M1 macrophages and its role on cancer outcomes

Cited in

(10)

• Mathematical investigation of innate immune responses to lung cancer: the role of macrophages with mixed phenotypes
• Investigation into the role of macrophages heterogeneity on solid tumour aggregations
• A SIMPLE MATHEMATICAL MODEL OF NON-SMALL CELL LUNG CANCER INVOLVING MACROPHAGES AND CD8+ T CELLS
• Modelling the continuum of macrophage phenotypes and their role in inflammation
• A bulk-surface mechanobiochemical modelling approach for single cell migration in two-space dimensions
• Modeling bistable dynamics arising from macrophage-tumor interactions in the tumor microenvironment
• A mechanical model for the failure of reconstructive breast implant surgery due to capsular contracture
• The impact of T-cell exhaustion dynamics on tumour-immune interactions and tumour growth
• Mathematical model of tumor-macrophage interactions: elucidating the tumor-driven macrophage phenotype reprogramming
• Mathematical modelling of the contribution of senescent fibroblasts to basement membrane digestion during carcinoma invasion

Describes a project that uses

Uses Software

• ode45
• ode23s
• MATLAB ODE suite
• Ode15s
• Matlab
• ode23
• ode113

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