Impact of estrogen population pharmacokinetics on a QSP model of mammary stem cell differentiation into myoepithelial cells

DOI10.3934/MATH.2021631MaRDI QIDQ2671114zbMATH OpenOpenAlexFDO

Authors Justin Le Sauteur-Robitaille, Zhe Si Yu, Morgan Craig

Publication date 3 June 2022

Published in AIMS Mathematics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.3934/math.2021631

zbMATH Keywords

breast cancerestrogenmammary myoepithelial cellsmammary stem cellspharmacokinetic variabilityquantitative systems pharmacology

Mathematics Subject Classification ID

General biology and biomathematics (92B05) Pathology, pathophysiology (92C32)

Cites work

• A mathematical model of granulopoiesis incorporating the negative feedback dynamics and kinetics of G-CSF/neutrophil binding and internalization
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• Modelling human granulopoiesis under poly-chemotherapy with G-CSF support
• Neutrophil dynamics during concurrent chemotherapy and G-CSF administration: mathematical modelling guides dose optimisation to minimise neutropenia
• The complex effect of granulocyte colony-stimulating factor on human granulopoiesis analyzed by a new physiologically-based mathematical model

Cited in

(1)

• Deconstructing the contributions of heterogeneity to combination treatment of hormone-sensitive breast cancer

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