Local and global sensitivity analysis of spheroid and xenograft models of the acid-mediated development of tumor malignancy

DOI10.1016/J.APM.2022.05.006MaRDI QIDQ2109734zbMATH OpenOpenAlexFDO

Authors Frederika Rentzeperis, Dorothy Wallace

Publication date 21 December 2022

Published in Applied Mathematical Modelling (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.apm.2022.05.006

zbMATH Keywords

sensitivity analysistumor modelWarburg effecttranslational medicine

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites work

• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• A methodology for performing global uncertainty and sensitivity analysis in systems biology
• A model for spheroid versus monolayer response of SK-N-SH neuroblastoma cells to treatment with 15-deoxy-\(PGJ_2\)
• Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model
• Predictive modeling of neuroblastoma growth dynamics in xenograft model after bevacizumab anti-VEGF therapy
• Sensitivity analysis of a nonlinear lumped parameter model of HIV infection dynamics

Cited in

(2)

• A simulation of parental and glycolytic tumor phenotype competition predicts observed responses to pH changes and increased glycolysis after anti-VEGF therapy
• Modelling acidosis and the cell cycle in multicellular tumour spheroids

Describes a project that uses

Uses Software

• Matlab

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