A model for spheroid versus monolayer response of SK-N-SH neuroblastoma cells to treatment with 15-deoxy-PGJ₂

DOI10.1155/2016/3628124zbMATH Open1423.92123DBLPjournals/cmmm/WallaceDCCHRP16OpenAlexW2557441389WikidataQ38723201 ScholiaQ38723201MaRDI QIDQ2011775FDOQ2011775

Authors: Ann Dunham, Paula X. Chen, Michelle Chen, Milan Huynh, Evan Rheingold, Olivia Prosper, Dorothy Wallace 

Publication date: 4 August 2017

Published in: Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1155/2016/3628124

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zbMATH Keywords

15-deoxy-\(PGJ_2\)monolayer responseneuroblastoma cells treatmenttumor spheroid growth

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Cited In (7)

• Targeting cellular DNA damage responses in cancer: an in vitro-calibrated agent-based model simulating monolayer and spheroid treatment responses to ATR-inhibiting drugs
• On a 2D model of avascular tumor with weak Allee effect
• Predictive modeling of neuroblastoma growth dynamics in xenograft model after bevacizumab anti-VEGF therapy
• Local and global sensitivity analysis of spheroid and xenograft models of the acid-mediated development of tumor malignancy
• Comparison of drug inhibitory effects \((\mathrm{IC}_{50})\) in monolayer and spheroid cultures
• A simulation of parental and glycolytic tumor phenotype competition predicts observed responses to pH changes and increased glycolysis after anti-VEGF therapy
• Predicting the results of competition between two breast cancer lines grown in 3-D spheroid culture

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