Comparison of drug inhibitory effects (IC₅₀) in monolayer and spheroid cultures

DOI10.1101/2020.05.05.079285MaRDI QIDQ2189964zbMATH OpenOpenAlexWikidataFDO

Authors Catherine Berrouet, Naika Dorilas, Katarzyna A. Rejniak, Necibe Tuncer

Publication date 17 June 2020

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International

Full work available at URL https://doi.org/10.1101/2020.05.05.079285

zbMATH Keywords

\(\mathrm{IC}_{50}\) valuesdrugs efficacymonolayer versus spheroid cell cultures

Mathematics Subject Classification ID

Computational methods for problems pertaining to biology (92-08) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

• A single cell-based model of the ductal tumour microarchitecture
• Derivation and experimental comparison of cell-division probability densities
• Emergence of anti-cancer drug resistance: exploring the importance of the microenvironmental niche via a spatial model
• Implicit-Explicit Methods for Time-Dependent Partial Differential Equations
• Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
• Time-stepping schemes for moving grid finite elements applied to reaction-diffusion systems on fixed and growing domains

Cited in

(1)

• Histology-guided mathematical model of tumor oxygenation: sensitivity analysis of physical and computational parameters

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