Comparison of drug inhibitory effects \((\mathrm{IC}_{50})\) in monolayer and spheroid cultures

DOI10.1101/2020.05.05.079285zbMath1444.92030OpenAlexW3020913470WikidataQ96110787 ScholiaQ96110787MaRDI QIDQ2189964

Catherine Berrouet, Necibe Tuncer, Naika Dorilas, Katarzyna A. Rejniak

Publication date: 17 June 2020

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1101/2020.05.05.079285

zbMATH Keywords

\(\mathrm{IC}_{50}\) valuesdrugs efficacymonolayer versus spheroid cell cultures

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50) Cell biology (92C37) Computational methods for problems pertaining to biology (92-08)

Cites Work

• Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases
• A single cell-based model of the ductal tumour microarchitecture
• Derivation and experimental comparison of cell-division probability densities
• Time-stepping schemes for moving grid finite elements applied to reaction-diffusion systems on fixed and growing domains
• Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model
• Implicit-Explicit Methods for Time-Dependent Partial Differential Equations

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