Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation
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Publication:2339991
DOI10.1007/S00285-008-0214-YzbMATH Open1311.92096OpenAlexW2120022359WikidataQ37433585 ScholiaQ37433585MaRDI QIDQ2339991FDOQ2339991
Authors: John P. Sinek, Sandeep Sanga, Xiaoming Zheng, M. Ferrari, Vittorio Cristini, Hermann B. Frieboes 
Publication date: 15 April 2015
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/s00285-008-0214-y
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Cites Work
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- Modelling and mathematical problems related to tumor evolution and its interaction with the immune system
- Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development
- Mathematical modelling of the influence of blood rheological properties upon adaptative tu\-mour-induced angiogenesis
- Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method
- Fractional step methods applied to a chemotaxis model
- An improved geometry-aware curvature discretization for level set methods: Application to tumor growth
- An adaptive mesh algorithm for evolving surfaces: simulations of drop breakup and coalescence
- Evolving interfaces via gradients of geometry-dependent interior Poisson problems: application to tumor growth
- Mathematical modelling of drug transport in tumour multicell spheroids and monolayer cultures
- Modelling the response of spatially structured tumours to chemotherapy: drug kinetics
- A new approach to modelling the formation of necrotic regions in tumours
Cited In (18)
- System identification in tumor growth modeling using semi-empirical eigenfunctions
- Micropharmacology: an in silico approach for assessing drug efficacy within a tumor tissue
- Optimisation of cancer drug treatments using cell population dynamics
- Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs
- Pharmacokinetic/pharmacodynamic modeling of combination-chemotherapy for lung cancer
- A phenotype-structured model to reproduce the avascular growth of a tumor and its interaction with the surrounding environment
- Regularity analysis and numerical resolution of the pharmacokinetics (PK) equation for cisplatin with random coefficients and initial conditions
- Computational modeling of tumor response to vascular-targeting therapies. I: Validation
- Numerical investigation of the pharmacokinetics and pharmacodynamics of the chemotherapeutic drug in avascular and vascular stages of a brain tumor
- Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
- Cancer stem cell, niche and EGFR decide tumor development and treatment response: a bio-computational simulation study
- Model of drug delivery to populations composed of two cell types
- Estimation of drug and tumor properties using novel hybrid meta-heuristic methods
- Comparison of drug inhibitory effects \((\mathrm{IC}_{50})\) in monolayer and spheroid cultures
- Modelling the effects of cell-cycle heterogeneity on the response of a solid tumour to chemotherapy: biological insights from a hybrid multiscale cellular automaton model
- Mathematical approach to predict the drug effects on cancer stem cell models
- Three-dimensional multispecies nonlinear tumor growth. II: Tumor invasion and angiogenesis
- Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
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