Micropharmacology: an in silico approach for assessing drug efficacy within a tumor tissue

DOI10.1007/S11538-018-0402-XMaRDI QIDQ2334402zbMATH OpenOpenAlexWikidataFDO

Authors Aleksandra Karolak, Katarzyna A. Rejniak

Publication date 7 November 2019

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082744

zbMATH Keywords

drug penetrationhypoxia-activated pro-drugsmicroPKPDsingle-cell pharmacologytargeted therapeuticstumor tissue architecture

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites work

• Boundary integral solutions of coupled Stokes and Darcy flows
• Computational modeling of tumor response to vascular-targeting therapies. I: Validation
• The method of regularized stokeslets
• The method of regularized Stokeslets in three dimensions:  Analysis, validation, and application to helical swimming

Cited in

(12)

• Tissue transport affects how treatment scheduling increases the efficacy of chemotherapeutic drugs
• Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies
• What can mathematics do for drug development?
• A hybrid spatiotemporal model of PCa dynamics and insights into optimal therapeutic strategies
• An integrated multiscale mechanistic model for cancer drug therapy
• Numerical modeling of space-time distribution of a drug agent in biological tissue
• Identification of an anticancerous drug model in brain tissues using Adomian/Alienor methods
• Penetration and distribution efficacy of chemotherapeutic drugs in biological tissues: a computational investigation
• Numerical investigation of the pharmacokinetics and pharmacodynamics of the chemotherapeutic drug in avascular and vascular stages of a brain tumor
• Computational model of the cancer necrotic core formation in a tumor-on-a-chip device
• Optimization of HAP administration in cancer therapy
• A mathematical feasibility argument for the use of aptamers in chemotherapy and imaging

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