Micropharmacology: an in silico approach for assessing drug efficacy within a tumor tissue

DOI10.1007/s11538-018-0402-xzbMath1426.92024OpenAlexW2790788848WikidataQ50103495 ScholiaQ50103495MaRDI QIDQ2334402

Katarzyna A. Rejniak, Aleksandra Karolak

Publication date: 7 November 2019

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082744

zbMATH Keywords

drug penetrationhypoxia-activated pro-drugsmicroPKPDsingle-cell pharmacologytargeted therapeuticstumor tissue architecture

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

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Cites Work

• Computational modeling of tumor response to vascular-targeting therapies. I: Validation
• Boundary integral solutions of coupled Stokes and Darcy flows
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• The method of regularized Stokeslets in three dimensions:  Analysis, validation, and application to helical swimming