A Mathematical Tumor Model with Immune Resistance and Drug Therapy: An Optimal Control Approach
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Publication:2767515
DOI10.1080/10273660108833067zbMATH Open0985.92023OpenAlexW2013304036MaRDI QIDQ2767515FDOQ2767515
Authors: L. G. de Pillis, A. Radunskaya 
Publication date: 30 May 2002
Published in: Journal of Theoretical Medicine (Search for Journal in Brave)
Full work available at URL: https://eudml.org/doc/226953
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Medical applications (general) (92C50) Applications of optimal control and differential games (49N90)
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- Mathematical modeling and dynamic analysis of anti-tumor immune response
- Optimal bounded controls problem for bilinear systems
- Identifying and characterising the impact of excitability in a mathematical model of tumour-immune interactions
- Reinforcement learning-based control of drug dosing for cancer chemotherapy treatment
- Optimal response to chemotherapy for a mathematical model of tumor-immune dynamics
- Stability of a mathematical model with piecewise constant arguments for tumor-immune interaction under drug therapy
- Multi-input optimal control problems for combined tumor anti-angiogenic and radiotherapy treatments
- The combined effects of optimal control in cancer remission
- Predictive drug dosage control through a Fokker-Planck observer
- Mathematical modeling of the immune-chemotherapeutic treatment of breast cancer under some control parameters
- On the role of pharmacometrics in mathematical models for cancer treatments
- The tumor growth paradox and immune system-mediated selection for cancer stem cells
- A two-compartment model interacting with dynamic drugs
- On optimal delivery of combination therapy for tumors
- Mathematical model of chimeric anti-gene receptor (CAR) T cell therapy with presence of cytokine
- Global solvability and optimal control to a haptotaxis cancer invasion model with two cancer cell species
- A two-phenotype model of immune evasion by cancer cells
- Analysis of the dynamics of a tumor-immune system with chemotherapy and immunotherapy and quadratic optimal control
- Modelling of tumor cells regression in response to chemotherapeutic treatment
- New observations on optimal cancer treatments for a fractional tumor growth model with and without singular kernel
- Role of immunotherapy in tumor-immune interaction: perspectives from fractional-order modelling and sensitivity analysis
- Optimal control of tumour-immune model with time-delay and immuno-chemotherapy
- The effect of finite duration inputs on the dynamics of a system: proposing a new approach for cancer treatment
- Optimal control for selected cancer chemotherapy ODE models: a view on the potential of optimal schedules and choice of objective function
- Numerical optimal control of a size-structured PDE model for metastatic cancer treatment
- Robust feedback design for combined therapy of cancer
- An immune system-tumour interactions model with discrete time delay: model analysis and validation
- Personalized drug administration for cancer treatment using model reference adaptive control
- Combination therapies and intra-tumoral competition: insights from mathematical modeling
- Optimal chemotherapy in cancer treatment: state dependent Riccati equation control and extended Kalman filter
- A mathematical model of periodically pulsed chemotherapy: Tumor recurrence and metastasis in a competitive environment
- Mixed immunotherapy and chemotherapy of tumors: feedback design and model updating schemes
- On probabilistic certification of combined cancer therapies using strongly uncertain models
- Computational modeling of tumor response to vascular-targeting therapies. I: Validation
- Effects of the obesity on optimal control schedules of chemotherapy on a cancerous tumor
- Optimal control for a mathematical model for chemotherapy with pharmacometrics
- The chaos and optimal control of cancer model with complete unknown parameters
- Therapy strategy in tumour cells and immune system interaction mathematical model
- A cancer model for the angiogenic switch
- Modelling lymphoma therapy and outcome
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- Delay differential model for tumour-immune response with chemoimmunotherapy and optimal control
- The dynamics of an optimally controlled tumor model: A case study
- Dynamical behaviour of a tumour-immune model focusing on the dosage of targeted chemotherapeutic drug
- Interactions between the immune system and cancer: A brief review of non-spatial mathematical models
- Mixed immunotherapy and chemotherapy of tumors: modeling, applications and biological interpretations
- Cancer immunotherapy, mathematical modeling and optimal control
- Dynamical behaviour of a tumor-immune system with chemotherapy and optimal control
- Spatial avascular growth of tumor in a homogeneous environment
- Mathematical modelling and analysis of the tumor treatment regimens with pulsed immunotherapy and chemotherapy
- Bifurcation analysis of the cancer virotherapy system with time delay and diffusion
- A time delay model of tumour-immune system interactions: global dynamics, parameter estimation, sensitivity analysis
- Periodic and chaotic dynamics in a map-based model of tumor-immune interaction
- Two-compartment model interacting with proliferating regulatory factor
- A cellular automata model of tumor-immune system interactions
- Combined therapy for treating solid tumors with chemotherapy and angiogenic inhibitors
- Chemotherapy for tumors: An analysis of the dynamics and a study of quadratic and linear optimal controls
- Combination of virotherapy and chemotherapy with optimal control for combating cancer
- Some promising approaches to tumor-immune modelling
- A mathematical model for chemoimmunotherapy of chronic lymphocytic leukemia
- Bifurcation and chaos analysis of tumor growth
- Mathematical models of leukaemia and its treatment: a review
- Optimal control of cancer treatments: mathematical models for the tumor microenvironment
- Chaos in a tumor growth model with delayed responses of the immune system
- Stability and bifurcation analysis of a mathematical model for tumor-immune interaction with piecewise constant arguments of delay
- Cost-effectiveness analysis of optimal strategy for tumor treatment
- Optimal and suboptimal protocols for a class of mathematical models of tumor anti-angiogenesis
- Mathematical analysis of a tumour-immune interaction model: a moving boundary problem
- Dynamic analysis of an antitumor model and investigation of the therapeutic effects for different treatment regimens
- Bifurcation Analysis in a Cancer Growth Model
- Dynamics of tumor growth: chemotherapy and integrative oncology
- Global dynamics of a breast cancer competition model
- Influence of distributed delays on the dynamics of a generalized immune system cancerous cells interactions model
- A mathematical model for the effect of obesity on cancer growth and on the immune system response
- Efficiency of cancer treatments: \textit{in silico experiments}
- An adaptive pharmacokinetic optimal control approach in chemotherapy for heterogeneous tumor
- Stability analysis of the singular points and Hopf bifurcations of a tumor growth control model
- Optimal control for biphasic chemotaxis model of tumour growth under chemotherapy
- Bifurcation, multistability in the dynamics of tumor growth and electronic simulations by the use of Pspice
- Extinction and persistence of a tumor-immune model with white noise and pulsed comprehensive therapy
- A control theory approach to cancer remission aided by an optimal therapy
- Mixed therapy in cancer treatment for personalized drug administration using model reference adaptive control
- Optimal control homotopy perturbation method for cancer model
- Can the original equations of a dynamical system be retrieved from observational time series?
- Analytical study of a modified-ABC fractional order breast cancer model
- Optimal control problem for a general reaction-diffusion tumor-immune interaction system of mixed immunotherapy and chemotherapy
- Dynamic analysis of a tumor-immune system under Allee effect
- A dynamic simulation of the immune system response to inhibit and eliminate abnormal cells
- Insights into the dynamics of blood conveying gold nanoparticles on a curved surface when suction, thermal radiation, and Lorentz force are significant: the case of non-Newtonian Williamson fluid
- A nonlinear transport-diffusion model for the interactions between immune system cells and HPV-infected cells
- Robust domain of attraction estimation for a tumor growth model
- Constrained bilinear control problem: application to a cancer chemotherapy model
- On the role of the objective in the optimization of compartmental models for biomedical therapies
- Learning-based sensitivity analysis and feedback design for drug delivery of mixed therapy of cancer in the presence of high model uncertainties
- Iterative method for estimating the robust domains of attraction of non-linear systems: application to cancer chemotherapy model with parametric uncertainties
- Effects of delayed immune-activation in the dynamics of tumor-immune interactions
- Persistence and extinction of the tumor-immune stochastic model with effector cells and cytokines
- Optimal control of tumor-lymphatic model with immuno-chemotherapy
- Mathematical modeling and bifurcation analysis for a biological mechanism of cancer drug resistance
- A mathematical model of stroma-supported allometric tumor growth
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