Optimization of virotherapy for cancer

DOI10.1007/S11538-009-9456-0zbMath1185.92058OpenAlexW2016165386WikidataQ51789593 ScholiaQ51789593MaRDI QIDQ2380843

Huitian Lu, Jung-Han Kimn, Željko Bajzer, David Dingli, Matthew Biesecker

Publication date: 12 April 2010

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s11538-009-9456-0

zbMATH Keywords

optimization methodsmodeling virotherapy

Mathematics Subject Classification ID

Numerical optimization and variational techniques (65K10) Applications of optimal control and differential games (49N90) Medical applications (general) (92C50)

Related Items (15)

Memory versus effector immune responses in oncolytic virotherapies ⋮ Bifurcations and multistability in a virotherapy model with two time delays ⋮ Slow-fast model and therapy optimization for oncolytic treatment of tumors ⋮ Dynamics of the tumor-immune-virus interactions: convergence conditions to tumor-only or tumor-free equilibrium points ⋮ Multiscale moving boundary modelling of cancer interactions with a fusogenic oncolytic virus: the impact of syncytia dynamics ⋮ Treatment of glioma with virotherapy and TNF-\(\alpha\) inhibitors: analysis as a dynamical system ⋮ Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics ⋮ Analysis of a mathematical model for tumor therapy with a fusogenic oncolytic virus ⋮ Multi-stability and multi-instability phenomena in a mathematical model of tumor-immune-virus interactions ⋮ The role of the innate immune system in oncolytic virotherapy ⋮ Modeling treatment of cancer using virotherapy with generalized logistic growth of tumor cells ⋮ Backward Hopf bifurcation in a mathematical model for oncolytic virotherapy with the infection delay and innate immune effects ⋮ A mathematical model for cell cycle-specific cancer virotherapy ⋮ Unnamed Item ⋮ Treatment strategies for combining immunostimulatory oncolytic virus therapeutics with dendritic cell injections

Cites Work

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• Modeling and analysis of a virus that replicates selectively in tumor cells
• On a class of optimal control problems with state jumps
• The dynamics of an optimally controlled tumor model: A case study
• Modeling of cancer virotherapy with recombinant measles viruses
• Conceptual frameworks for mathematical modeling of tumor growth dynamics
• Determination of the optimal therapeutic protocols in cancer immunotherapy
• The competitive dynamics between tumor cells, a replication-competent virus and an immune response
• Mathematical modeling of cancer radiovirotherapy
• Optimal Control Applied to Cell-Cycle-Specific Cancer Chemotherapy

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