Relating cell shape and mechanical stress in a spatially disordered epithelium using a vertex-based model

DOI10.1093/IMAMMB/DQX008zbMATH Open1404.92023arXiv1611.04744OpenAlexW3105715916WikidataQ47656420 ScholiaQ47656420MaRDI QIDQ4559655FDOQ4559655

Alexander Nestor-Bergmann, Georgina Goddard, Sarah Woolner, Oliver E. Jensen

Publication date: 4 December 2018

Published in: Mathematical Medicine and Biology: A Journal of the IMA (Search for Journal in Brave)

Abstract: Using a popular vertex-based model to describe a spatially disordered planar epithelial monolayer, we examine the relationship between cell shape and mechanical stress at the cell and tissue level. Deriving expressions for stress tensors starting from an energetic formulation of the model, we show that the principal axes of stress for an individual cell align with the principal axes of shape, and we determine the bulk effective tissue pressure when the monolayer is isotropic at the tissue level. Using simulations for a monolayer that is not under peripheral stress, we fit parameters of the model to experimental data for Xenopus embryonic tissue. The model predicts that mechanical interactions can generate mesoscopic patterns within the monolayer that exhibit long-range correlations in cell shape. The model also suggests that the orientation of mechanical and geometric cues for processes such as cell division are likely to be strongly correlated in real epithelia. Some limitations of the model in capturing geometric features of Xenopus epithelial cells are highlighted.

Full work available at URL: https://arxiv.org/abs/1611.04744

zbMATH Keywords

mechanical stresscell shapevertex-based modelepithelial monolayer

Mathematics Subject Classification ID

Biomechanics (92C10) Developmental biology, pattern formation (92C15) Cell biology (92C37)

Cited In (9)

• Mechanical cell competition in heterogeneous epithelial tissues
• Minimal cellular automaton model with heterogeneous cell sizes predicts epithelial colony growth
• Force networks, torque balance and Airy stress in the planar vertex model of a confluent epithelium
• Competition between epithelial tissue elasticity and surface tension in cancer morphogenesis
• Relaxation and noise-driven oscillations in a model of mitotic spindle dynamics
• A statistical mechanics approach to describe cell reorientation under stretch
• Approximate Bayesian computation reveals the importance of repeated measurements for parameterising cell-based models of growing tissues
• Cells adapt their shapes with their experienced stiffness: a geometrical approach to differentiation
• Bayesian parameter inference for epithelial mechanics

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