Interim Design Modifications in Time-to-Event Studies

DOI10.17192/z2012.0144 10.1080/01621459.2011.644141; 10.17192/z2012.0144zbMath1261.62098OpenAlexW2010230345MaRDI QIDQ4916467

Sebastian Irle, Helmut Schäfer

Publication date: 22 April 2013

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/01621459.2011.644141

zbMATH Keywords

Conditional distributionClinical trialAdaptive designConditional rejection probabilityCRP principleLogrank statistic

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Exact distribution theory in statistics (62E15) Testing in survival analysis and censored data (62N03)

Related Items

Confirmatory adaptive group sequential designs for single‐arm phase II studies with multiple time‐to‐event endpoints

Uses Software

• R

Cites Work

• Unnamed Item
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• Phase 2 and 3 Combination Designs to Accelerate Drug Development