A Unified Theory of Two-Stage Adaptive Designs

DOI10.1198/016214502388618852MaRDI QIDQ4468503zbMATH OpenOpenAlexFDO

Authors Qing Liu, Michael A. Proschan, Gordon Pledger

Publication date 10 June 2004

Published in Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1198/016214502388618852

zbMATH Keywords

confidence intervalstype I error ratepivotal quantityunbiased estimatorsconditional error functionadaptive p-valuetwo-stage adaptive designs

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Point estimation (62F10) Applications of statistics to biology and medical sciences; meta analysis (62P10) Foundations and philosophical topics in statistics (62A01) Parametric tolerance and confidence regions (62F25) Characterization and structure theory of statistical distributions (62E10)

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Cited in

(23)

• Information in a two-stage adaptive optimal design
• Are Flexible Designs Sound?
• A covariate-adjusted adaptive design for two-stage clinical trials with survival data
• A signature enrichment design with Bayesian adaptive randomization
• Two-stage Adaptive Designs in Nonlinear Mixed Effects Models: Application to Pharmacokinetics in Children
• Interim design modifications in time-to-event studies
• On design and inference for two-stage adaptive clinical trials with dependent data
• An optimal sequential design in ethical allocation with an adaptive interim analysis
• A Bayesian adaptive design for two-stage clinical trials with survival data
• Point estimation for adaptive trial designs. I: A methodological review
• Bias induced by adaptive dose-finding designs
• Fixed-width confidence interval for two-stage response-adaptive designs in ridit analysis
• On the efficiency of adaptive designs for flexible interim decisions in clinical trials
• Adaptive multivariate global testing
• Benefit–Risk Evaluation of Multi-Stage Adaptive Designs
• A distribution-free approach for selecting better treatment through an ethical allocation
• Probabilistic foundation of confirmatory adaptive designs
• Tests and classification methods in adaptive designs with applications
• New results on optimal conditional error functions for adaptive two-stage designs
• SEAMLESS PHASE II/III CLINICAL TRIALS WITH COVARIATE ADAPTIVE RANDOMIZATION
• An optimal design in a two-stage ethical allocation based on U-statistics
• A comparison between two treatments in a clinical trial with an ethical allocation design
• Sequential methods in multi-arm clinical trials

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