Interim Design Modifications in Time-to-Event Studies

DOI10.17192/z2012.0144 10.1080/01621459.2011.644141; 10.17192/z2012.0144zbMath1261.62098MaRDI QIDQ4916467

Sebastian Irle, Helmut Schäfer

Publication date: 22 April 2013

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/01621459.2011.644141

zbMATH Keywords

Conditional distribution; Clinical trial; Adaptive design; Conditional rejection probability; CRP principle; Logrank statistic

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

62E15: Exact distribution theory in statistics

62N03: Testing in survival analysis and censored data

Related Items

Confirmatory adaptive group sequential designs for single‐arm phase II studies with multiple time‐to‐event endpoints

Uses Software

• R

Cites Work

• Unnamed Item
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• Designed Extension of Studies Based on Conditional Power
• A Unified Theory of Two-Stage Adaptive Designs
• Adaptive Sample Size Calculations in Group Sequential Trials
• Evaluation of Experiments with Adaptive Interim Analyses
• Phase 2 and 3 Combination Designs to Accelerate Drug Development