Interim Design Modifications in Time-to-Event Studies

DOI10.1080/01621459.2011.644141zbMath1261.62098OpenAlexW2010230345MaRDI QIDQ4916467

Sebastian Irle, Helmut Schäfer

Publication date: 22 April 2013

Published in: Journal of the American Statistical Association (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1080/01621459.2011.644141

zbMATH Keywords

Conditional distributionClinical trialAdaptive designConditional rejection probabilityCRP principleLogrank statistic

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Exact distribution theory in statistics (62E15) Testing in survival analysis and censored data (62N03)

Related Items (1)

Confirmatory adaptive group sequential designs for single‐arm phase II studies with multiple time‐to‐event endpoints

Uses Software

• R

Cites Work

• Unnamed Item
• Sequential analysis of the proportional hazards model
• Group sequential tests with censored survival data adjusting for covariates
• Sequential Analysis of Survival Times in Clinical Trials
• Central limit theorems for local martingales
• The asymptotic joint distribution of the efficient scores test for the proportional hazards model calculated over time
• Designed Extension of Studies Based on Conditional Power
• A Unified Theory of Two-Stage Adaptive Designs
• Adaptive Sample Size Calculations in Group Sequential Trials
• Evaluation of Experiments with Adaptive Interim Analyses
• Phase 2 and 3 Combination Designs to Accelerate Drug Development

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