Learning Quadratic Receptive Fields from Neural Responses to Natural Stimuli

DOI10.1162/NECO_A_00463zbMath1448.92048DBLPjournals/neco/RajanMT13arXiv1209.0121OpenAlexW2117026160WikidataQ38100825 ScholiaQ38100825MaRDI QIDQ5378221

Olivier Marre, Gašper Tkačik, Kanaka Rajan

Publication date: 12 June 2019

Published in: Neural Computation (Search for Journal in Brave)

Abstract: Models of neural responses to stimuli with complex spatiotemporal correlation structure often assume that neurons are only selective for a small number of linear projections of a potentially high-dimensional input. Here we explore recent modeling approaches where the neural response depends on the quadratic form of the input rather than on its linear projection, that is, the neuron is sensitive to the local covariance structure of the signal preceding the spike. To infer this quadratic dependence in the presence of arbitrary (e.g. naturalistic) stimulus distribution, we review several inference methods, focussing in particular on two information-theory-based approaches (maximization of stimulus energy or of noise entropy) and a likelihood-based approach (Bayesian spike-triggered covariance, extensions of generalized linear models). We analyze the formal connection between the likelihood-based and information-based approaches to show how they lead to consistent inference. We demonstrate the practical feasibility of these procedures by using model neurons responding to a flickering variance stimulus.

Full work available at URL: https://arxiv.org/abs/1209.0121

Mathematics Subject Classification ID

General biostatistics (92B15) Neural biology (92C20)

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