Time delay in necrotic core formation (Q814655)

A simple model of avascular solid tumor dynamics is studied in this paper. The model is derived on the basis of reaction-diffusion dynamics and mass conservation law. They introduce time delay in a cell proliferation process. In the case studied in this paper, the model reduces to one ordinary functional differential equation. The main goal of this paper is to study the process of the necrotic core formation and possible influence of the delay on it. Existence, uniqueness and stability of the steady state are discussed. Numerical simulations are performed.