sigminer

CRANsigminerMaRDI QIDQ68655

Extract, Analyze and Visualize Mutational Signatures for Genomic Variations

Huimin Li, Tao Wu, Ziyu Tao, Xue-Song Liu, Shixiang Wang

Last update: 12 December 2023

Copyright license: MIT license, File License

Software version identifier: 2.2.0, 0.1.9, 0.1.11, 1.0.0, 1.0.3, 1.0.5, 1.0.6, 1.0.7, 1.0.13, 1.0.16, 1.0.19, 1.1.0, 1.2.1, 1.2.4, 1.2.5, 2.0.0, 2.0.1, 2.0.2, 2.0.3, 2.0.4, 2.0.5, 2.1.0, 2.1.1, 2.1.2, 2.1.3, 2.1.4, 2.1.5, 2.1.6, 2.1.7, 2.1.8, 2.1.9, 2.2.2, 2.3.0

Description

Genomic alterations including single nucleotide substitution, copy number alteration, etc. are the major force for cancer initialization and development. Due to the specificity of molecular lesions caused by genomic alterations, we can generate characteristic alteration spectra, called 'signature' (Wang, Shixiang, et al. (2021) <doi:10.1371/journal.pgen.1009557> & Alexandrov, Ludmil B., et al. (2020) <doi:10.1038/s41586-020-1943-3> & Steele Christopher D., et al. (2022) <doi:10.1038/s41586-022-04738-6>). This package helps users to extract, analyze and visualize signatures from genomic alteration records, thus providing new insight into cancer study.

Cites work

• Copy number signature analysis tool and its application in prostate cancer reveals distinct mutational processes and clinical outcomes
• The repertoire of mutational signatures in human cancer
• Signatures of copy number alterations in human cancer

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