bi bi reaction ordered mechanism (ODE model)

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continuous-time model

deterministic model

dimensional model

dynamic model

mathematical model

nonlinear model

Available identifiers

MaRDI QIDQ6675335

bi bi reaction model following an ordered mechanism

Description

Ordinary differential equations for the rates of change of all chemical species (substrate 1 and 2, enzyme, enzyme - substrate 1 - complex, enzyme - substrate 1 - substrate 2 - complex, enzyme - product 1 - product 2 - complex, enzyme - product 1 complex and product 1 and 2 in a Bi Bi Reaction following the Ordered Mechanism. kᵢ with positive or negative i represents the rate constant of the forward- or backward-reaction i-th reaction step.

List of contained entities

bi bi reaction ordered mechanism ODE system	$\begin{array}{cc}\frac{d{c}_{S_1}}{dt}& =k_{-1}{c}_{E{S}_1}-k_1{c}_E{c}_{S_1}\\ \frac{d{c}_{S_2}}{dt}& =k_{-2}{c}_{E{S}_1{S}_2}-k_2{c}_{E{S}_1}{c}_{S_2}\\ \frac{d{c}_{E{S}_1}}{dt}& =k_1{c}_E{c}_{S_1}+k_{-2}{c}_{E{S}_1{S}_2}-k_{-1}{c}_{E{S}_1}-k_2{c}_{E{S}_1}{c}_{S_2}\\ \frac{d{c}_{E{S}_1{S}_2}}{dt}& =k_2{c}_{E{S}_1}{c}_{S_2}+k_{-3}{c}_{E{P}_1{P}_2}-k_{-2}{c}_{E{S}_1{S}_2}-k_3{c}_{E{S}_1{S}_2}\\ \frac{d{c}_{E{P}_1{P}_2}}{dt}& =k_3{c}_{E{S}_1{S}_2}+k_{-4}{c}_{E{P}_1}{c}_{P_2}-k_{-3}{c}_{E{P}_1{P}_2}-k_4{c}_{E{P}_1{P}_2}\\ \frac{d{c}_{E{P}_1}}{dt}& =k_4{c}_{E{P}_1{P}_2}+k_{-5}{c}_E{c}_{P_1}-k_{-4}{c}_{E{P}_1}{c}_{P_2}-k_5{c}_{E{P}_1}\\ \frac{d{c}_{P_1}}{dt}& =k_5{c}_{E{P}_1}-k_{-5}{c}_E{c}_{P_1}\\ \frac{d{c}_{P_2}}{dt}& =k_4{c}_{E{P}_1{P}_2}-k_{-4}{c}_{E{P}_1}{c}_{P_2}\\ \frac{d{c}_E}{dt}& =k_{-1}{c}_{E{S}_1}+k_5{c}_{E{P}_1}-k_1{c}_E{c}_{S_1}-k_{-5}{c}_E{c}_{P_1}\\ \end{array}$
	$\frac{d{c}_{E{P}_1{P}_2}}{dt}$ represents reaction rate of enzyme - product 1 - product 2 complex
	$\frac{d{c}_{E{P}_1}}{dt}$ represents reaction rate of enzyme - product 1 complex
	$\frac{d{c}_{E{S}_1{S}_2}}{dt}$ represents reaction rate of enzyme - substrate 1 - substrate 2 complex
	$\frac{d{c}_{E{S}_1}}{dt}$ represents reaction rate of enzyme - substrate 1 complex
	$\frac{d{c}_E}{dt}$ represents reaction rate of enzyme
	$\frac{d{c}_{P_1}}{dt}$ represents reaction rate of product 1
	$\frac{d{c}_{P_2}}{dt}$ represents reaction rate of product 2
	$\frac{d{c}_{S_1}}{dt}$ represents reaction rate of substrate 1
	$\frac{d{c}_{S_2}}{dt}$ represents reaction rate of substrate 2
	$c_{E{P}_1{P}_2}$ represents enzyme - product 1 - product 2 complex concentration
	$c_{E{P}_1}$ represents enzyme - product 1 complex concentration
	$c_{E{S}_1{S}_2}$ represents enzyme - substrate 1 - substrate 2 complex concentration
	$c_{E{S}_1}$ represents enzyme - substrate 1 complex concentration
	$c_E$ represents enzyme concentration
	$c_{P_1}$ represents product 1 concentration
	$c_{P_2}$ represents product 2 concentration
	$c_{S_1}$ represents substrate 1 concentration
	$c_{S_2}$ represents substrate 2 concentration
	$k_{-1}$ represents reaction rate constant
	$k_{-2}$ represents reaction rate constant
	$k_{-3}$ represents reaction rate constant
	$k_{-4}$ represents reaction rate constant
	$k_{-5}$ represents reaction rate constant
	$k_1$ represents reaction rate constant
	$k_2$ represents reaction rate constant
	$k_3$ represents reaction rate constant
	$k_4$ represents reaction rate constant
	$k_5$ represents reaction rate constant
	$t$ represents time
enzyme conservation	$c_{E_0}=c_E+c_{EX}$
	$c_{EX}$ represents complexed enzyme concentration
	$c_{E_0}$ represents enzyme concentration
	$c_E$ represents enzyme concentration
initial enzyme - product 1 - complex concentration (bi bi reaction ordered - ODE model)	$c_{E{P}_1}(t=0)=c_{E{P}_{1_0}}$	initial condition
	$c_{E{P}_1}$ represents concentration
	$t$ represents time
initial enzyme - product 1 - product 2 - complex concentration (bi bi reaction ordered - ODE model)	$c_{E{P}_1{P}_2}(t=0)=c_{{E{P}_1{P}_2}_0}$	initial condition
	$c_{P{S}_1{P}_2}$ represents concentration
	$t$ represents time
initial enzyme - substrate 1 - complex concentration (bi bi reaction ordered - ODE model)	$c_{E{S}_1}(t=0)=c_{{E{S}_1}_0}$	initial condition
	$c_{E{S}_1}$ represents concentration
	$t$ represents time
initial enzyme - substrate 1 - substrate 2 - complex concentration (bi bi reaction ordered - ODE model)	$c_{E{S}_1{S}_2}(t=0)=c_{{E{S}_1{S}_2}_0}$	initial condition
	$c_{E{S}_1{S}_2}$ represents concentration
	$t$ represents time
initial enzyme concentration (bi bi reaction ordered - ODE model)	$c_E(t=0)=c_{E_0}$	initial condition
	$c_E$ represents concentration
	$t$ represents time
initial product 1 concentration (bi bi reaction ordered - ODE model)	$c_{P_1}(t=0)=c_{P_{1,0}}$	initial condition
	$c_{P_1}$ represents concentration
	$t$ represents time
initial product 2 concentration (bi bi reaction ordered - ODE model)	$c_{{\mathrm{P}}_2}(t=0)=c_{{\mathrm{P}}_{2,0}}$	initial condition
	$c_{P_2}$ represents concentration
	$t$ represents time
initial substrate 1 concentration (bi bi reaction ordered - ODE model)	$c_{S_1}(t=0)=c_{S_{1,0}}$	initial condition
	$c_{S_1}$ represents concentration
	$t$ represents time
initial substrate 2 concentration (bi bi reaction ordered - ODE model)	$c_{{\mathrm{S}}_2}(t=0)=c_{{\mathrm{S}}_{2,0}}$	initial condition
	$c_{{\mathrm{S}}_2}$ represents concentration
	$t$ represents time
law of mass action	$v=k\prod _{i=1}^n{c}_i$
	$c_i$ represents concentration
	$k$ represents reaction rate constant
	$n$ represents molecularity
	$v$ represents reaction rate
mass balance	${\delta }_t+\mathrm{\nabla }F=0$

List of computational tasks

parameter estimation of enzyme kinetics

sensitivity analysis of complex kinetic systems

simulation of complex kinetic systems

Mathematical models specializing bi bi reaction ordered mechanism (ODE model)

bi bi reaction ordered mechanism Michaelis Menten model with product 1 (steady state assumption)	assumes	steady state assumption
bi bi reaction ordered mechanism Michaelis Menten model with product 2 (steady state assumption)	assumes	steady state assumption
bi bi reaction ordered mechanism Michaelis Menten model with products 1 and 2 (steady state assumption)	assumes	steady state assumption
bi bi reaction ordered mechanism Michaelis Menten model without products (steady state assumption)	assumes	steady state assumption

Further items linking to bi bi reaction ordered mechanism (ODE model)

Item	Property
bi bi reaction following ordered mechanism	modelled by

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