stochastic signalling of G‑protein coupled receptors model

Community: MathModDB

continuous-time model

mathematical model

probabilistic model

Available identifiers

MaRDI QIDQ6771923

signalling pathway model from receptor activation over the G-protein cycle to the calcium channel inhibition

List of contained entities

G-protein activation	$f_{11}=k_{11}\cdot x_R\cdot x_{\alpha \text{GDP}\beta \gamma }$
	$k_{11}$ represents reaction constant for G-protein activation
	$x_R$ represents number of receptor molecules
	$x_{{\alpha }_{GDP}\beta \gamma }$ represents number of G-protein molecules
	$f_{11}$ represents propensity of G-protein activation
degradation of internalised receptor	$f_8=k_8\cdot x_{R{L}_w}$
	$k_8$ represents reaction constant for degradation of internalised receptor
	$x_{R{L}_w}$ represents number of internalised receptor
	$f_8$ represents propensity for the degradation of internalised receptor
degradation of the reaction partner	$f_9=k_9\cdot x_M$
	$k_9$ represents reaction constant for the degradation of the reaction partner
	$x_M$ represents number of reaction partner molecules
	$f_9$ represents propensity of degradation of the reaction partner
dissociation into α- and βγ-subunits	$f_2=k_2\cdot x_{RL}\cdot x_{\alpha \text{GDP}\beta \gamma }$
	$k_2$ represents reaction constant for dissociation into α- and βγ-subunits
	$x_{RL}$ represents number of receptor-ligand complex molecules
	$x_{{\alpha }_{GDP}\beta \gamma }$ represents number of G-protein molecules
	$f_2$ represents propensity of dissociation into α- and βγ-subunits
hydrolysis of GTP	$f_3=k_3\cdot x_{\alpha \text{GTP}}$
	$k_3$ represents reaction constant for hydrolysis of GTP
	$x_{{\alpha }_{GTP}}$ represents number of alpha subunits (with GTP attached)
	$f_3$ represents propensity of hydrolysis of GTP
inhibition of membrane calcium channel	$f_5=k_5\cdot x_{\beta \gamma }\cdot x_{{\text{Ca}}_{\text{on}}}$
	$k_5$ represents reaction constant for inhibition of membrane calcium channel
	$x_{\beta \gamma }$ represents number of βγ molecules
	$x_{C{a}_{on}}$ represents number of active calcium channels
	$f_5$ represents propensity of inhibition of membrane calcium channel
internalisation of receptor–ligand complex	$f_4=k_4\cdot x_{RL}\cdot x_M$
	$k_4$ represents reaction constant for internalisation of receptor–ligand complex
	$x_{RL}$ represents number of receptor-ligand complex molecules
	$f_4$ represents propensity of internalisation of receptor–ligand complex
	$x_M$ represents number of reaction partner molecules
internalised receptor recycled to the cell membrane	$f_7=k_7\cdot x_{R{L}_w}$
	$k_7$ represents reaction constant for internalised receptor recycled to the cell membrane
	$x_{R{L}_w}$ represents number of internalised receptor
	$f_7$ represents propensity of internalised receptor recycled to the cell membrane
jump in the system state	$x\mapsto x+v_j$
	$x$ represents state of system vector
	$v_j$ represents stoichiometric vectors
receptor–ligand complex creation	$f_1=k_1\cdot x_L\cdot x_R$
	$k_1$ represents reaction constant for receptor-ligand complex creation
	$x_R$ represents number of receptor molecules
	$x_L$ represents number of ligand molecules
	$f_1$ represents propensity of receptor-ligand complex creation
reformation of G-protein complex and opening of calcium channel	$f_6=k_6\cdot x_{\alpha \text{GDP}}\cdot x_{{\text{Ca}}_{\text{off}}}$
	$k_6$ represents reaction constant for reformation of G-protein complex and opening of calcium channel
	$x_{{\alpha }_{GDP}}$ represents number of alpha subunits (loaded with GDP)
	$x_{C{a}_{off}}$ represents number of inactive calcium channels
	$f_6$ represents propensity of reformation of G-protein complex and opening of calcium channel
standard chemical master equation	$\frac{d}{dt}p(𝒙,t)=\sum _{j=1}^{11}[f_j(𝒙-{𝒗}_j)p(𝒙-{𝒗}_j,t)-f_j(𝒙)p(𝒙,t)]$
	$p(x,t)$ represents system state probability
	$X(t)$ represents Markov jump process
	$v_j$ represents stoichiometric vectors
	$f_j$ represents propensity functions for the signalling of g‑protein coupled receptors reactions
	$x$ represents state of system vector
vanishing of ligand	$f_{10}=k_{10}\cdot x_L$
	$k_{10}$ represents reaction constant for the vanishing of ligand
	$x_L$ represents number of ligand molecules
	$f_{10}$ represents propensity of the vanishing of ligand

Described at:

Modelling altered signalling of G‑protein coupled receptors in inflamed environment to advance drug design

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