Hill model (enzyme kinetics)

Community: MathModDB

deterministic model

dimensional model

mathematical model

nonlinear model

static model

Available identifiers

MaRDI QIDQ6775834

cooperative model describing enzyme reaction rates, named after Terrell L. Hill

Description

The Hill model in enzyme kinetics is an empirical rate law used to describe cooperative substrate binding and the resulting sigmoidal dependence of initial reaction velocity on substrate concentration. It generalizes the Michaelis–Menten equation by introducing a Hill coefficient that quantifies positive or negative cooperativity among substrate-binding events. The model captures catalytic saturation behavior and provides parameters describing maximal velocity and substrate sensitivity. When the Hill coefficient equals one, the model reduces to the classical non-cooperative Michaelis–Menten form. The Hill enzyme-kinetics model is applied to cooperative or allosteric enzymes in biochemistry and systems biology.

List of contained entities

Hill velocity equation	$v_0=\frac{V_{max}{c}_S^{n_H}}{K_{0.5}^{n_H}+c_S^{n_H}}$
	$v_0$ represents initial reaction rate
	$n_H$ represents Hill coefficient
	$c_S$ represents substrate concentration
	$K_{0.5}$ represents half saturation constant (Hill kinetics)
	$V_{max}$ represents Hill limiting reaction rate

List of computational tasks

nonlinear parameter estimation (Hill enzyme kinetics model)

Mathematical models specializing Hill model (enzyme kinetics)

uni uni reaction (Michaelis Menten model without product - steady state assumption)

assumes

no cooperativity assumption

Further items linking to Hill model (enzyme kinetics)

Item	Property
initial reaction rate of uni uni reaction without product	modelled by

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