nonlinear parameter estimation (Hill dose-response model)

Community: MathModDB

computational task	nonlinear task

Available identifiers

MaRDI QIDQ6775839

nonlinear estimation of Hill dose–response model parameters, named after Terrell L. Hill

Description

This task performs nonlinear parameter estimation using dose–response data based on the Hill dose–response model. It estimates the maximal system response, the half-maximal concentration, and the cooperativity exponent by fitting the nonlinear sigmoidal Hill equation directly to observed concentration–effect measurements. Nonlinear regression eliminates distortions from linear transformations and yields robust estimates across a wide range of cooperative behaviors. The resulting parameters describe drug efficacy, potency, and the steepness of the dose–response relationship. This approach is widely used in pharmacology, toxicology, and pharmacokinetic–pharmacodynamic modeling.

List of contained entities

Hill coefficient
Hill dose-response equation	$E = \frac{E_{m a x} c_{D}^{n_{H}}}{E C_{50}^{n_{H}} + c_{D}^{n_{H}}}$
	$E$ represents observed response
	$E C_{50}$ represents half maximal effective concentration
	$c_{D}$ represents drug concentration
	$n_{H}$ represents Hill coefficient
	$E_{m a x}$ represents maximal response

drug concentration
half maximal effective concentration
maximal response
observed response

Further items linking to nonlinear parameter estimation (Hill dose-response model)

Item	Property
Hill model (dose-response)	used by

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