A generalized Gaussian process model for computer experiments with binary time series
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Abstract: Non-Gaussian observations such as binary responses are common in some computer experiments. Motivated by the analysis of a class of cell adhesion experiments, we introduce a generalized Gaussian process model for binary responses, which shares some common features with standard GP models. In addition, the proposed model incorporates a flexible mean function that can capture different types of time series structures. Asymptotic properties of the estimators are derived, and an optimal predictor as well as its predictive distribution are constructed. Their performance is examined via two simulation studies. The methodology is applied to study computer simulations for cell adhesion experiments. The fitted model reveals important biological information in repeated cell bindings, which is not directly observable in lab experiments.
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Cited in
(11)- Modeling binary time series using Gaussian processes with application to predicting sleep states
- Estimation for binary models generated by Gaussian autoregressive processes
- Renewal model for dependent binary sequences
- Binary time series modeling with application to adhesion frequency experiments
- Calibration for computer experiments with binary responses and application to cell adhesion study
- Optimal Simulator Selection
- binaryGP
- Computer model calibration with time series data using deep learning and quantile regression
- Ice model calibration using semicontinuous spatial data
- On Negative Transfer and Structure of Latent Functions in Multioutput Gaussian Processes
- Analysis of multivariate non-Gaussian functional data: a semiparametric latent process approach
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