A multiscale analysis of diffusions on rapidly varying surfaces

DOI10.1007/S00332-015-9237-XMaRDI QIDQ2344115zbMATH OpenOpenAlexFDO

Authors Andrew B. Duncan, Charles M. Elliott, Grigorios A. Pavliotis, A. M. Stuart

Publication date 12 May 2015

Published in Journal of Nonlinear Science (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1311.1007, https://authors.library.caltech.edu/69078/

zbMATH Keywords

effective diffusion tensorHelfrich elastic membranehomogenizationLaplace-Beltramilateral diffusionmultiscale analysis

Mathematics Subject Classification ID

Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Applications of stochastic analysis (to PDEs, etc.) (60H30)

Abstract: Lateral diffusion of molecules on surfaces plays a very important role in various biological processes, including lipid transport across the cell membrane, synaptic transmission and other phenomena such as exo- and endocytosis, signal transduction, chemotaxis and cell growth. In many cases, the surfaces can possess spatial inhomogeneities and/or be rapidly changing shape. Using a generalisation of the model for a thermally excited Helfrich elastic membrane, we consider the problem of lateral diffusion on quasi-planar surfaces, possessing both spatial and temporal fluctuations. Using results from homogenisation theory, we show that, under the assumption of scale separation between the characteristic length and time scales of the membrane fluctuations and the characteristic scale of the diffusing particle, the lateral diffusion process can be well approximated by a Brownian motion on the plane with constant diffusion tensor $D$ which depends in a highly nonlinear way on the detailed properties of the surface. The effective diffusion tensor will depend on the relative scales of the spatial and temporal fluctuations and, for different scaling regimes, we prove the existence of a macroscopic limit in each case.

Recommendations

• Homogenization of lateral diffusion on a random surface
• A model for surface diffusion of trans-membrane proteins on lipid bilayers
• Multiscale analysis and simulation of a signaling process with surface diffusion
• Is Brownian motion sensitive to geometry fluctuations?
• The mathematical theory of Itô diffusions on hypersurfaces, with applications to NMR relaxation problems

Cites work

• A First Course in Continuum Mechanics
• Apparent 2-D diffusivity in a ruffled cell membrane
• Asymptotic Series for Singularly Perturbed Kolmogorov–Fokker–Planck Equations
• Averaging a transport equation with small diffusion and oscillating velocity
• Brownian Motion on a Hypersurface
• Brownian motion with respect to time-changing Riemannian metrics, applications to Ricci flow
• Computation of geometric partial differential equations and mean curvature flow
• Conductivity of a Medium Containing a Dense Array of Perfectly Conducting Spheres or Cylinders or Nonconducting Cylinders
• Elliptic partial differential equations of second order
• Ergodicity for SDEs and approximations: locally Lipschitz vector fields and degenerate noise.
• Finite element methods for surface PDEs
• Fluctuations in Markov processes. Time symmetry and martingale approximation.
• Heterogeneous Multiscale FEM for Diffusion Problems on Rough Surfaces
• Homogenization for inertial particles in a random flow
• Homogenization in a Periodic and Time-Dependent Potential
• Homogenization of linear and semilinear second order parabolic PDEs with periodic coefficients: A probabilistic approach
• scientific article; zbMATH DE number 5164440 (Why is no real title available?)
• scientific article; zbMATH DE number 5366820 (Why is no real title available?)
• scientific article; zbMATH DE number 3665495 (Why is no real title available?)
• scientific article; zbMATH DE number 3782462 (Why is no real title available?)
• scientific article; zbMATH DE number 51724 (Why is no real title available?)
• scientific article; zbMATH DE number 3586282 (Why is no real title available?)
• scientific article; zbMATH DE number 3627589 (Why is no real title available?)
• scientific article; zbMATH DE number 651015 (Why is no real title available?)
• scientific article; zbMATH DE number 1851001 (Why is no real title available?)
• Inverse problems: a Bayesian perspective
• Markov Chains and Stochastic Stability
• Multiscale Methods
• Stochastic analysis on manifolds
• Stochastic processes in physics and chemistry.
• The Fokker-Planck equation. Methods of solutions and applications.
• The Mathematical Theory of Finite Element Methods

Cited in

(11)

• The mathematical theory of Itô diffusions on hypersurfaces, with applications to NMR relaxation problems
• Apparent 2-D diffusivity in a ruffled cell membrane
• The surface diffusion flow on rough phase spaces
• scientific article; zbMATH DE number 3856872 (Why is no real title available?)
• Homogenization of lateral diffusion on a random surface
• Lateral diffusion of membrane proteins at cell membrane
• Linear parabolic problems in random moving domains
• Bulk-mediated Surface Diffusion on a Cylinder in the Fast Exchange Limit
• Rough homogenization for Langevin dynamics on fluctuating Helfrich surfaces
• Error analysis of a hybrid numerical method for optimal control problem governed by parabolic PDEs in random cylindrical domains
• Multiscale analysis for diffusion-driven neutrally stable states

Describes a project that uses

Uses Software

• PPM

This page was built for publication: A multiscale analysis of diffusions on rapidly varying surfaces

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2344115)