Multiscale analysis and simulation of a signaling process with surface diffusion
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bulk-surface problemshomogenizationintercellular signalingnonlinear parabolic equationsreceptor-ligand interactionssurface diffusionsurface finite elements
Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) Nonlinear parabolic equations (35K55) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Cell biology (92C37)
Abstract: We present and analyse a model for cell signalling processes in biological tissues. The model includes diffusion and nonlinear reactions on the cell surfaces, and both inter- and intracellular signalling. Using techniques from the theory of two-scale convergence as well the unfolding method, we show convergence of the solutions to the model to solutions of a two-scale macroscopic problem. We also present a two-scale bulk-surface finite element method for the approximation of the macroscopic model. We report on some benchmarking results as well as numerical simulations in a biologically relevant regime that illustrate the influence of cell-scale heterogeneities on macroscopic concentrations.
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Cited in
(5)- A multiscale analysis of diffusions on rapidly varying surfaces
- Multiscale modelling and analysis of signalling processes in tissues with non-periodic distribution of cells
- Homogenization of fast diffusion on surfaces with a two-step method and an application to \(T\)-cell signaling
- Strong two-scale convergence and corrector result for a receptor-based model of intercellular communication
- Multiscale modelling, analysis and simulation of cancer invasion mediated by bound and soluble enzymes
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