A nonparametric empirical Bayes framework for large-scale multiple testing
From MaRDI portal
Abstract: We propose a flexible and identifiable version of the two-groups model, motivated by hierarchical Bayes considerations, that features an empirical null and a semiparametric mixture model for the non-null cases. We use a computationally efficient predictive recursion marginal likelihood procedure to estimate the model parameters, even the nonparametric mixing distribution. This leads to a nonparametric empirical Bayes testing procedure, which we call PRtest, based on thresholding the estimated local false discovery rates. Simulations and real-data examples demonstrate that, compared to existing approaches, PRtest's careful handling of the non-null density can give a much better fit in the tails of the mixture distribution which, in turn, can lead to more realistic conclusions.
Recommendations
- Large-Scale Simultaneous Hypothesis Testing
- Extended Likelihood Approach to Large-Scale Multiple Testing
- A nonparametric mixture approach to density and null proportion estimation in large‐scale multiple comparison problems
- Two‐group Poisson‐Dirichlet mixtures for multiple testing
- Comment: ``Microarrays, empirical Bayes and the two-group model
Cited in
(30)- A deconvolution path for mixtures
- Bayesian nonparametric multiple testing
- A semiparametric scale-mixture regression model and predictive recursion maximum likelihood
- A survey of nonparametric mixing density estimation via the predictive recursion algorithm
- Estimating a mixing distribution on the sphere using predictive recursion
- On spike and slab empirical Bayes multiple testing
- Unsupervised empirical Bayesian multiple testing with external covariates
- Empirical Bayes analysis of RNA sequencing experiments with auxiliary information
- Imprecise Dirichlet process with application to the hypothesis test on the probability that \(X \leq Y\)
- Model selection for maternal hypertensive disorders with symmetric hierarchical Dirichlet processes
- Application of the empirical Bayes approach to nonparametric testing for high-dimensional data
- An empirical Bayes optimal discovery procedure based on semiparametric hierarchical mixture models
- Convergence rate for predictive recursion estimation of finite mixtures
- False Discovery Rate Smoothing
- Asymptotically minimax empirical Bayes estimation of a sparse normal mean vector
- An Approximate Bayesian Marginal Likelihood Approach for Estimating Finite Mixtures
- A Robustified Posterior for Bayesian Inference on a Large Number of Parallel Effects
- Resampling‐Based Empirical Bayes Multiple Testing Procedures for Controlling Generalized Tail Probability and Expected Value Error Rates: Focus on the False Discovery Rate and Simulation Study
- Asymptotically optimal nonparametric empirical Bayes via predictive recursion
- Large-Scale Simultaneous Hypothesis Testing
- Extended likelihood approach to large-scale multiple testing
- Two‐group Poisson‐Dirichlet mixtures for multiple testing
- Revisiting consistency of a recursive estimator of mixing distributions
- A PRticle filter algorithm for nonparametric estimation of multivariate mixing distributions
- Multiple hypothesis screening using mixtures of non-local distributions with applications to genomic studies
- Anytime-valid and asymptotically efficient inference driven by predictive recursion
- An improved permutation-based FDR estimator for heavy-tailed data
- Comment: ``Microarrays, empirical Bayes and the two-group model
- Nonparametric Bayesian multiple testing for longitudinal performance stratification
- Empirical null and false discovery rate inference for exponential families
This page was built for publication: A nonparametric empirical Bayes framework for large-scale multiple testing
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2903318)
