Empirical null and false discovery rate inference for exponential families
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Publication:999664
Abstract: In large scale multiple testing, the use of an empirical null distribution rather than the theoretical null distribution can be critical for correct inference. This paper proposes a ``mode matching method for fitting an empirical null when the theoretical null belongs to any exponential family. Based on the central matching method for -scores, mode matching estimates the null density by fitting an appropriate exponential family to the histogram of the test statistics by Poisson regression in a region surrounding the mode. The empirical null estimate is then used to estimate local and tail false discovery rate (FDR) for inference. Delta-method covariance formulas and approximate asymptotic bias formulas are provided, as well as simulation studies of the effect of the tuning parameters of the procedure on the bias-variance trade-off. The standard FDR estimates are found to be biased down at the far tails. Correlation between test statistics is taken into account in the covariance estimates, providing a generalization of Efron's ``wing function for exponential families. Applications with statistics are shown in a family-based genome-wide association study from the Framingham Heart Study and an anatomical brain imaging study of dyslexia in children.
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- Multiple testing approaches for hypotheses in integrative genomics
- Power-enhanced multiple decision functions controlling family-wise error and false discovery rates
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- On improving some adaptive BH procedures controlling the FDR under dependence
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- On fuzzy familywise error rate and false discovery rate procedures for discrete distributions
- Empirical null estimation using zero-inflated discrete mixture distributions and its application to protein domain data
- Nonparametric false discovery rate control for identifying simultaneous signals
- A novel characterization of the generalized family wise error rate using empirical null distributions
- False discovery rate control with unknown null distribution: is it possible to mimic the oracle?
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