False discovery rate analysis of brain diffusion direction maps
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Publication:2482973
DOI10.1214/07-AOAS133zbMATH Open1137.62033arXiv0803.3740OpenAlexW1978687463MaRDI QIDQ2482973FDOQ2482973
Authors: Armin Schwartzman, Robert F. Dougherty, Jonathan Taylor 
Publication date: 30 April 2008
Published in: The Annals of Applied Statistics (Search for Journal in Brave)
Abstract: Diffusion tensor imaging (DTI) is a novel modality of magnetic resonance imaging that allows noninvasive mapping of the brain's white matter. A particular map derived from DTI measurements is a map of water principal diffusion directions, which are proxies for neural fiber directions. We consider a study in which diffusion direction maps were acquired for two groups of subjects. The objective of the analysis is to find regions of the brain in which the corresponding diffusion directions differ between the groups. This is attained by first computing a test statistic for the difference in direction at every brain location using a Watson model for directional data. Interesting locations are subsequently selected with control of the false discovery rate. More accurate modeling of the null distribution is obtained using an empirical null density based on the empirical distribution of the test statistics across the brain. Further, substantial improvements in power are achieved by local spatial averaging of the test statistic map. Although the focus is on one particular study and imaging technology, the proposed inference methods can be applied to other large scale simultaneous hypothesis testing problems with a continuous underlying spatial structure.
Full work available at URL: https://arxiv.org/abs/0803.3740
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Directional data; spatial statistics (62H11) Applications of statistics to biology and medical sciences; meta analysis (62P10) Order statistics; empirical distribution functions (62G30) Image analysis in multivariate analysis (62H35) Neural biology (92C20) Biomedical imaging and signal processing (92C55)
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Cited In (22)
- Nonparametric two-sample tests on homogeneous Riemannian manifolds, Cholesky decompositions and diffusion tensor image analysis
- Large-scale dependent multiple testing via hidden semi-Markov models
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- Procrustes metrics on covariance operators and optimal transportation of Gaussian processes
- Multiscale scanning in inverse problems
- A general framework for multiple testing dependence
- Heteroscedasticity-Adjusted Ranking and Thresholding for Large-Scale Multiple Testing
- Sticky central limit theorems on open books
- Integral transform methods in goodness-of-fit testing. II: The Wishart distributions
- Limit theorems for excursion sets of stationary random fields
- False Discovery Rate Smoothing
- Asymptotic conditional singular value decomposition for high-dimensional genomic data
- Maximum likelihood estimation of the log-concave component in a semi-parametric mixture with a standard normal density
- Statistics on manifolds and landmarks based image analysis: a nonparametric theory with applications
- Local tests for identifying anisotropic diffusion areas in human brain with DTI
- Scaling-rotation distance and interpolation of symmetric positive-definite matrices
- False Discovery Rate Control Under General Dependence By Symmetrized Data Aggregation
- Voxelwise single-subject analysis of imaging metabolic response to therapy in neuro-oncology
- Multiple testing of local maxima for detection of peaks in 1D
- Three testing perspectives on connectome data
- Efficient stratified testing procedure for a false discovery rate
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