admixr2

MaRDI QIDQ7370532CRANFDO

Authors H. van de Beek, P.A.J. Välitalo, L.B. Zwep, J.G.C. van Hasselt

Last update 16 September 2026

Copyright license GNU General Public License

Software version identifier PACKAGES.rds, 0.1.0, 0.2.0, 0.4.1

Description

Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data, for meta-analysis across studies. Integrates with the 'nlmixr2'/'rxode2' ecosystem via four estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH') estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.

Cites work

• Aggregate data modelling: A fast implementation for fitting pharmacometrics models to summary-level data in R
• Pharmacometric estimation methods for aggregate data, including data simulated from other pharmacometric models

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