admixr2 (Q7370532)
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Aggregate Data Modelling
| Language | Label | Description | Also known as |
|---|---|---|---|
| default for all languages | No label defined |
||
| English | admixr2 |
Aggregate Data Modelling |
Statements
Fit pharmacokinetic/pharmacodynamic (PK/PD) models to aggregate-level data (mean vector and covariance matrix per study) rather than individual-level data, for meta-analysis across studies. Integrates with the 'nlmixr2'/'rxode2' ecosystem via four estimation methods: a First-Order ('FO') analytical estimator, a Monte Carlo (MC) estimator, a Gauss-Hermite quadrature ('GH') estimator, and an Iterative Reweighting Monte Carlo ('IRMC') estimator. Methods are based on Välitalo (2021) <doi:10.1007/s10928-021-09760-1>; software described in van de Beek et al. (2025) <doi:10.1007/s10928-025-10011-w>.
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16 September 2026
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P.A.J. Välitalo
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L.B. Zwep
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J.G.C. van Hasselt
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