An optimal control problem in the study of liver kinetics

DOI10.1007/BF00940674MaRDI QIDQ2265965zbMATH OpenFDO

Authors Kjell Holmåker

Publication date 1986

Published in Journal of Optimization Theory and Applications (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/BF00940674

zbMATH Keywords

distribution of enzymes along the blood flowenzyme kineticsliver kineticsnecessary conditionsPontryagin's maximum principlesubstrate-inhibition kinetics

Mathematics Subject Classification ID

Optimality conditions for problems involving ordinary differential equations (49K15) Physiological, cellular and medical topics (92Cxx)

Review text

The enzyme activities in the liver are described by a system of ordinary differential equations. A certain substance in the blood is transformed twice by different kinds of enzymes. The mathematical problem is to determine the distribution of enzymes along the blood flow so that the outflow concentration of the once-transformed form of the substance is as small as possible. This problem has been considered before and solved for particular types of enzyme kinetics. In this paper, we solve the problem for more general types of kinetics (including substrate-inhibition kinetics). The methods used are also different in that the problem is considered as a problem of optimal control and Pontryagin's maximum principle is applied to derive necessary conditions.

Recommendations

• scientific article; zbMATH DE number 3845395
• Optimal control in liver kinetics
• Minimisation problems for implicit functionals defined by differential equations of liver kinetics
• Optimal control problems with applications to the elimination of substrate diffusing and convecting through immobilized enzyme
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Cites work

• scientific article; zbMATH DE number 3109695 (Why is no real title available?)
• Minimisation problems for implicit functionals defined by differential equations of liver kinetics
• Optimal control theory

Cited in

(8)

• Optimal control problems with applications to the elimination of substrate diffusing and convecting through immobilized enzyme
• A Class of Optimization Problems with Noncompact Constraints: General Results and Applications
• scientific article; zbMATH DE number 3845395 (Why is no real title available?)
• Minimisation problems for implicit functionals defined by differential equations of liver kinetics
• Optimal control in liver kinetics
• A Problem Decomposition Technique with Application to the Optimal Distribution of Enzymes
• On an optimal control problem describing lactate transport inhibition
• Application of optimal control techniques and advanced computing to the study of enzyme kinetics

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