Analytical evaluation of the 2-in-1 adaptive design for binary endpoints

DOI10.1002/SIM.70349MaRDI QIDQ6856632zbMATH OpenFDO

Authors Gosuke Homma, Takuma Yoshida

Publication date 18 February 2026

Published in Statistics in Medicine (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1002/SIM.70349

zbMATH Keywords

2-in-1 adaptive designbinary endpointexactpowertest sizetype I error rate

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A cautionary note on exact unconditional inference for a difference between two independent binomial proportions
• Design of randomized clinical trials with a binary endpoint: conditional versus unconditional analyses of a two-by-two table
• Exact Unconditional Sample Sizes for the 2 × 2 Binomial Trial
• Group sequential and confirmatory adaptive designs in clinical trials
• Methods and Applications of Sample Size Calculation and Recalculation in Clinical Trials
• On the criterion, that a given system of deviations from the probable in the case of a correlated system of variables is such that it can be reasonably supposed to have arisen from random sampling.
• P Values Maximized Over a Confidence Set for the Nuisance Parameter
• Raised conditional level of significance for the 2 × 2‐table when testing the equality of two probabilities
• Sample size re-estimation in clinical trials
• Significance Tests in Discrete Distributions
• Statistical Analysis of Contingency Tables
• Tests of significance for differences between percentages based on small numbers.

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