Bayesian crossover designs for generalized linear models

DOI10.1016/J.CSDA.2016.06.002MaRDI QIDQ1658721zbMATH OpenOpenAlexFDO

Authors Satya Prakash Singh, Siuli Mukhopadhyay

Publication date 15 August 2018

Published in Computational Statistics and Data Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1601.01955

zbMATH Keywords

count datalogistic regressionefficiencygeneralized estimating equationsBayesian designsgamma response

Mathematics Subject Classification ID

Computational methods for problems pertaining to statistics (62-08) Generalized linear models (logistic models) (62J12) Optimal statistical designs (62K05)

Abstract: This article discusses D-optimal Bayesian crossover designs for generalized linear models. Crossover trials with t treatments and p periods, for $t<=p$, are considered. The designs proposed in this paper minimize the log determinant of the variance of the estimated treatment effects over all possible allocation of the n subjects to the treatment sequences. It is assumed that the p observations from each subject are mutually correlated while the observations from different subjects are uncorrelated. Since main interest is in estimating the treatment effects, the subject effect is assumed to be nuisance, and generalized estimating equations are used to estimate the marginal means. To address the issue of parameter dependence a Bayesian approach is employed. Prior distributions are assumed on the model parameters which are then incorporated into the D-optimal design criterion by integrating it over the prior distribution. Three case studies, one with binary outcomes in a 4$imes$4 crossover trial, second one based on count data for a 2$imes$2 trial and a third one with Gamma responses in a 3$times$2 crossover trial are used to illustrate the proposed method. The effect of the choice of prior distributions on the designs is also studied.

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Cited in

(15)

• On Bayes and Nash experimental designs for hypothesis testing problems
• Exact Bayesian designs for count time series
• Comparing treatment effects for the \textit{AB} : \textit{BA} crossover design with continuous responses: an alternative nonparametric approach
• scientific article; zbMATH DE number 2024680 (Why is no real title available?)
• Optimal crossover designs for generalized linear models
• A general equivalence theorem for crossover designs under generalized linear models
• G-optimal grid designs for kriging models
• Optimal designs for some bivariate cokriging models
• Bayesian optimal stepped wedge design
• scientific article; zbMATH DE number 4155661 (Why is no real title available?)
• Optimal allocation of subjects in a matched pair cluster-randomized trial with fixed number of heterogeneous clusters
• Universally optimal multivariate crossover designs
• Min-max crossover designs for two treatments binary and Poisson crossover trials
• D‐optimal designs of mean‐covariance models for longitudinal data
• Some design considerations for cluster randomized trials with binary responses

Describes a project that uses

Uses Software

• SAS/STAT
• daewr
• SAS

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