Bayesian optimization for personalized dose-finding trials with combination therapies

DOI10.1093/JRSSSC/QLAE058MaRDI QIDQ6859253zbMATH OpenFDO

Authors James Willard, Shirin Golchi, Erica E. M. Moodie, Bruno Boulanger, Bradley P. Carlin

Publication date 12 February 2026

Published in Journal of the Royal Statistical Society. Series C. Applied Statistics (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1093/JRSSSC/QLAE058

zbMATH Keywords

Bayesian adaptive clinical trialdrug combinationGaussian processresponse heterogeneity

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

Cites work

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• Two‐Dimensional Dose Finding in Discrete Dose Space
• Utility-Based Optimization of Combination Therapy Using Ordinal Toxicity and Efficacy in Phase I/II Trials

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