clinDR

CRANclinDRMaRDI QIDQ128007FDOQ128007

Authors Mike K. Smith, Neal Thomas, Jing Wu

Last update 9 August 2023

Copyright license GNU General Public License, version 3.0, GNU General Public License, version 2.0

Software version identifier 2.3.5, 1.6, 1.7, 1.8, 1.9, 2.2.1, 2.3, 2.4.1

Description

Bayesian and ML Emax model fitting, graphics and simulation for clinical dose response. The summary data from the dose response meta-analyses in Thomas, Sweeney, and Somayaji (2014) <doi:10.1080/19466315.2014.924876> and Thomas and Roy (2016) <doi:10.1080/19466315.2016.1256229> Wu, Banerjee, Jin, Menon, Martin, and Heatherington(2017) <doi:10.1177/0962280216684528> are included in the package. The prior distributions for the Bayesian analyses default to the posterior predictive distributions derived from these references.

Cites work

• Meta-Analysis of Clinical Dose–Response in a Large Drug Development Portfolio
• Analysis of Clinical Dose–Response in Small-Molecule Drug Development: 2009–2014
• Clinical dose–response for a broad set of biological products: A model-based meta-analysis

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