Compartmental analysis of dynamic nuclear medicine data: models and identifiability

DOI10.1088/0266-5611/32/12/125010MaRDI QIDQ2957543zbMATH OpenOpenAlexFDO

Authors Fabrice Delbary, Sara Garbarino, Valentina Vivaldi

Publication date 26 January 2017

Published in Inverse Problems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1603.02266

zbMATH Keywords

compartmental analysisidentifiabilitynuclear medicine data

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Medical applications (general) (92C50)

Abstract: Compartmental models based on tracer mass balance are extensively used in clinical and pre-clinical nuclear medicine in order to obtain quantitative information on tracer metabolism in the biological tissue. This paper is the first of a series of two that deal with the problem of tracer coefficient estimation via compartmental modelling in an inverse problem framework. Specifically, here we discuss the identifiability problem for a general n-dimension compartmental system and provide uniqueness results in the case of two-compartment and three-compartment compartmental models. The second paper will utilize this framework in order to show how non-linear regularization schemes can be applied to obtain numerical estimates of the tracer coefficients in the case of nuclear medicine data corresponding to brain, liver and kidney physiology.

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Cites work

• Compartmental modelling of the uptake kinetics of the anti‐cancer agent topotecan in human breast cancer cells
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Cited in

(9)

• Multivariate regularized Newton and Levenberg-Marquardt methods: a comparison on synthetic data of tumor hypoxia in a kinetic framework
• Mathematical modeling of kinetics of iodine-containing radiotracers in nuclear medicine problems
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• A state space transformation can yield identifiable models for tracer kinetic studies with enrichment data
• Identifiability of directed-cycle and catenary linear compartmental models
• Exact parameter identification in PET pharmacokinetic modeling: extension to the reversible two tissue compartment model

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